Combe B
Service d'Immuno-Rhumatologie, Hôpital Lapeyronie, 34295 Montpellier, France.
Clin Exp Rheumatol. 2003 Sep-Oct;21(5 Suppl 31):S123-8.
This report is focused on two French multicenter cohorts of patients with early rheumatoid arthritis (RA). The first one is a community-based study which was started in 1993. It was mainly designed to identify prognostic factors of joint destruction, disability and remission in patients with early RA. The 3-year and 5-year results have been recently reported. Briefly, progression of joint damage was best predicted at baseline by radiographic scores, ESR, CRP, rheumatoid factor and DRB1*04 genes, and disability by disease activity including the HAQ score. Recently, the French Society of Rheumatology initiated a large national multicenter registry (800 patients), the "ESPOIR cohort study", that could serve as a database to allow investigations not only on diagnostic and prognostic markers, but also on etiologic, pathogenic and medico-economic factors among patients with early inflammatory arthritis who could later develop RA. The objectives, design and organization of this early arthritis registry are described.
本报告聚焦于两个法国早期类风湿关节炎（RA）患者的多中心队列。第一个是始于1993年的基于社区的研究。其主要目的是确定早期RA患者关节破坏、残疾和缓解的预后因素。最近已报告了3年和5年的结果。简而言之，基线时关节损伤的进展通过放射学评分、红细胞沉降率（ESR）、C反应蛋白（CRP）、类风湿因子和DRB1*04基因能得到最佳预测，而残疾情况则通过包括健康评估问卷（HAQ）评分在内的疾病活动度来预测。最近，法国风湿病学会启动了一项大型全国多中心注册研究（800名患者），即“ESPOIR队列研究”，该研究可作为一个数据库，不仅用于调查诊断和预后标志物，还用于调查可能随后发展为RA的早期炎症性关节炎患者的病因、发病机制和医学经济因素。本文描述了这个早期关节炎注册研究的目标、设计和组织情况。
