Rokicki Władysław, Strzałkowski Adam, Kłapcińska Barbara, Danch Alojzy, Sobczak Andrzej
Department of Pediatric Cardiology Medical University of Silesia, Katowice.
Wiad Lek. 2003;56(7-8):337-40.
There is a common view that free radicals may play an important role in tissue damage resulting from circulatory insufficiency, cardiosurgery etc. There are very few data concerning the involvement of free radical reactions in the newborns and infants suffering from congenital heart defects (CHD). Antioxidant status was evaluated in 41 newborns and infants under 1 year of age, among them 23 suffering from CHD (14 with left-to-right shunt and 9 with cyanotic heart defect) and 18 healthy controls. The study based on the assessment of activities of antioxidant enzymes in blood (superoxide dismutase, catalase and glutathione peroxidase), levels of low molecular weight antioxidants (vitamin E, uric acid and selenium) and the concentration of malondialdehyde (MDA) as a marker of lipid peroxidation. All subjects had low blood selenium concentration as compared to the level considered as being adequate. Infants suffering from CHD had lower, as compared to healthy controls, plasma vitamin E concentration. The difference was significant in the case of acyanotic ones. The activities of superoxide dismutase and catalase in infants with CHD were not significantly different from the respective values recorded in healthy controls. The activity of glutathione peroxidase in whole blood was the lowest in infants with cyanotic heart defect in whom lipid peroxidation, as evaluated by MDA level, was the most enhanced. Significantly higher plasma concentration of uric acid which may be interpreted as a positive mechanism enabling better protection of red blood cells from peroxidative damage was found in this group of infants. It is concluded that enhanced oxidative stress due to imbalance between prooxidant and antioxidant reactions appears to be associated with congenital heart defect pathology in infants.
有一种普遍观点认为，自由基可能在循环功能不全、心脏手术等导致的组织损伤中起重要作用。关于自由基反应在患有先天性心脏病（CHD）的新生儿和婴儿中的参与情况，数据非常少。对41名1岁以下的新生儿和婴儿进行了抗氧化状态评估，其中23名患有CHD（14名有左向右分流，9名有青紫型心脏缺陷），18名作为健康对照。该研究基于对血液中抗氧化酶（超氧化物歧化酶、过氧化氢酶和谷胱甘肽过氧化物酶）的活性、低分子量抗氧化剂（维生素E、尿酸和硒）的水平以及作为脂质过氧化标志物的丙二醛（MDA）浓度的评估。与被认为足够的水平相比，所有受试者的血硒浓度都很低。与健康对照相比，患有CHD的婴儿血浆维生素E浓度较低。在无青紫型婴儿中，这种差异很显著。患有CHD的婴儿中超氧化物歧化酶和过氧化氢酶的活性与健康对照中记录的相应值没有显著差异。青紫型心脏缺陷婴儿全血中的谷胱甘肽过氧化物酶活性最低，通过MDA水平评估，其脂质过氧化程度最高。在这组婴儿中发现血浆尿酸浓度显著更高，这可能被解释为一种积极机制，能更好地保护红细胞免受过氧化损伤。结论是，由于促氧化剂和抗氧化剂反应失衡导致的氧化应激增强似乎与婴儿先天性心脏病病理相关。
