Borella P, Montagna M T, Romano-Spica V, Stampi S, Stancanelli G, Triassi M, Bargellini A, Giacobazzi P, Vercilli F, Scaltriti S, Marchesi I, Napoli C, Tatò D, Spilotros G, Paglionico N, Quaranta G, Branca M, Tumbarello M, Laurenti P, Moscato U, Capoluongo E, De Luca G, Legnani P P, Leoni E, Sacchetti R, Zanetti F, Moro M, Ossi C, Lopalco L, Santarpia R, Conturso V, Ribera d'Alcalà G, Montegrosso S
Dipartimento di Scienze Igienistiche, Microbiologiche e Biostatistiche, Università degli Studi di Modena e Reggio Emilia.
Ann Ig. 2003 Sep-Oct;15(5):493-503.
A multicentric Italian investigation on legionnaires' disease is in course to clarify host factors as well as pathogen associated characteristics involved in the infection/disease. The main goal of the research plan is to account for some critical aspects concerning identification and prevention of legionellosis. To improve knowledge on factors associated with Legionella spp colonisation in hot waters, to detect cases and to characterize risk factors in subjects which develop pneumonia are specific objectives of the research programme. Preliminary results show that hot waters of houses and hotels are frequently contaminated (22.6% and 54.6%, respectively), mainly by L. pneumophila. Microbial concentrations were low in domestic waters (<1.000 ufc/l), but higher in samples from the hotels (geom. mean 1.85 x 10(3) ufc/l). Warming system, age of the plant, type of building were risk factors significantly associated with Legionella spp positivity. The active surveillance on patients affected by pneumonia with search for Legionella urinary antigen allowed the identification of 34 cases, 3 of which of nosocomial origin, corresponding to 4.2% of the screened pneumonia. After informed consent, 26 subjects were recruited for a case-control-study to clarify risk factors for the disease.
意大利一项关于军团病的多中心调查正在进行，以阐明宿主因素以及感染/疾病中涉及的病原体相关特征。该研究计划的主要目标是说明军团病识别和预防方面的一些关键问题。提高对与热水中嗜肺军团菌定植相关因素的认识、检测病例以及确定患肺炎患者的危险因素是该研究项目的具体目标。初步结果显示，家庭和酒店的热水经常受到污染（分别为22.6%和54.6%），主要是嗜肺军团菌。生活用水中的微生物浓度较低（<1000 cfu/l），但酒店样本中的浓度较高（几何平均数为1.85×10³ cfu/l）。供暖系统、设备使用年限、建筑类型是与嗜肺军团菌阳性显著相关的危险因素。对肺炎患者进行主动监测并检测军团菌尿抗原，共识别出34例病例，其中3例为医院感染病例，占筛查肺炎病例的4.2%。在获得知情同意后，招募了26名受试者进行病例对照研究，以明确该病的危险因素。
