Streeten Elizabeth A, McBride Daniel J, Lodge Amy L, Pollin Toni I, Stinchcomb David G, Agarwala Richa, Schäffer Alejandro A, Shapiro Jay R, Shuldiner Alan R, Mitchell Braxton D
Division of Endocrinology, Diabetes and Nutrition, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA.
J Bone Miner Res. 2004 Feb;19(2):308-13. doi: 10.1359/JBMR.0301223. Epub 2003 Dec 16.
The incidence of hip fracture was estimated in a community of Old Order Amish and compared with available data from non-Amish whites. Hip fracture rates were 40% lower in the Amish, and the Amish also experienced higher BMD.
Understanding the patterns of fracture risk across populations could reveal insights about bone health and lead to the earlier detection and prevention of osteoporosis. Toward this aim, we compared hip fracture incidence and bone mineral density (BMD) between an Old Order Amish (OOA) community, characterized by a rural and relatively active lifestyle, and non-Amish U.S. whites.
All hospital admissions for hip fracture among OOA individuals in Lancaster County, PA, were identified between 1995 and 1998 from four area hospitals. Hip fracture incidence was calculated by cross-referencing an available Anabaptist genealogy database with communities located within these hospital service areas and compared with non-Amish whites obtained from National Hospital Discharge data. Additionally, BMD at the hip was compared between 287 Amish subjects and non-Amish whites from the National Health and Nutrition Examination Survey III survey.
OOA experienced 42% fewer hip fractures than would be expected had they experienced the same rate of hip fracture as observed in non-Amish whites (p < 0.01) and a higher mean BMD that was significant in women (p < 0.05) but not men. Further evaluation of lifestyle and/or genetic differences between Amish and non-Amish populations may shed insights into etiologic factors influencing hip fracture risk.
对一个旧秩序阿米什社区的髋部骨折发病率进行了估算，并与非阿米什白人的现有数据进行了比较。阿米什人的髋部骨折发生率低40%，而且他们的骨密度也更高。
了解不同人群的骨折风险模式可以揭示有关骨骼健康的见解，并有助于更早地发现和预防骨质疏松症。为了实现这一目标，我们比较了以农村和相对活跃的生活方式为特征的旧秩序阿米什（OOA）社区与非阿米什美国白人之间的髋部骨折发病率和骨矿物质密度（BMD）。
1995年至1998年间，从宾夕法尼亚州兰开斯特县的四家地区医院中确定了所有OOA个体因髋部骨折而住院的情况。通过将现有的再洗礼派家谱数据库与这些医院服务区域内的社区进行交叉比对来计算髋部骨折发病率，并与从国家医院出院数据中获取的非阿米什白人进行比较。此外，还比较了287名阿米什受试者与第三次国家健康和营养检查调查中的非阿米什白人的髋部骨密度。
与非阿米什白人的髋部骨折发生率相同的情况下，OOA实际发生的髋部骨折比预期少42%（p<0.01），且平均骨密度更高，在女性中具有显著性差异（p<0.05），但在男性中无显著性差异。进一步评估阿米什人和非阿米什人群之间的生活方式和/或基因差异，可能会深入了解影响髋部骨折风险的病因因素。
