利用凝集素和新糖缀合物将药物靶向输送至结肠。

Drug targeting to the colon with lectins and neoglycoconjugates.

作者信息

Minko Tamara

机构信息

Department of Pharmaceutics, Ernest Mario School of Pharmacy Rutgers, The State University of New Jersey, 160 Frelinghuysen Road, Piscataway, NJ 08854-8020, USA.

出版信息

Adv Drug Deliv Rev. 2004 Mar 3;56(4):491-509. doi: 10.1016/j.addr.2003.10.017.

DOI:10.1016/j.addr.2003.10.017

PMID:14969755

Abstract

Targeting of drugs to specific sites of action provides several advantages over non-targeted drugs. These include the prevention of side effects of drugs on healthy tissues and enhancement of drug uptake by targeted cells. This review will cover traditional approaches of colon drug targeting as well as the use of lectins and neoglycoconjugates for the targeted delivery. Direct and reverse targeting strategies, potential molecular targets and targeting moieties for colon drug delivery, targeted drug delivery systems (DDS) for colon delivery, anticancer DDS targeted to colon cancer are examined. Directions of future development are discussed.

摘要

与非靶向药物相比，将药物靶向特定作用部位具有多个优势。这些优势包括预防药物对健康组织产生副作用以及增强靶向细胞对药物的摄取。本综述将涵盖结肠药物靶向的传统方法以及使用凝集素和新糖缀合物进行靶向递送。研究了直接和反向靶向策略、结肠药物递送的潜在分子靶点和靶向部分、用于结肠递送的靶向药物递送系统（DDS）、靶向结肠癌的抗癌DDS。并讨论了未来的发展方向。