Smart John D
Biomaterials and Drug Delivery Group, School of Pharmacy and Biomedical Sciences, University of Portsmouth, White Swan Road, Portsmouth PO1 2DT, UK.
Adv Drug Deliv Rev. 2004 Mar 3;56(4):481-9. doi: 10.1016/j.addr.2003.10.016.
The delivery of therapeutic agents to, or via, the oral cavity is limited by the efficient removal mechanisms that exist in this area. Lectins are proteins or glycoproteins that bind to specific sugar residues, and can, therefore, interact with the glycoconjugates present on cell surfaces or salivary mucins. Endogenous lectins could also be used as points of attachment for carbohydrate-containing delivery systems. This review considers the possibility of using lectins as targeting agents within the oral cavity and reports on some of the limited number of studies completed to date. As lectins are multifunctional molecules, the possibility of using them as both targeting and therapeutic agents is considered. Lectin-containing delivery systems are a potential innovation for targeted and prolonged therapy within the oral cavity, but considerations such as toxicity and cost will need to be addressed before their routine use becomes a reality.
治疗药物向口腔内或通过口腔给药受到该区域存在的高效清除机制的限制。凝集素是能与特定糖残基结合的蛋白质或糖蛋白，因此可与细胞表面或唾液粘蛋白上存在的糖缀合物相互作用。内源性凝集素也可用作含碳水化合物递送系统的附着点。本综述探讨了将凝集素用作口腔内靶向剂的可能性，并报告了迄今为止完成的一些有限研究。由于凝集素是多功能分子，因此考虑了将它们用作靶向剂和治疗剂的可能性。含凝集素的递送系统是口腔内靶向和延长治疗的潜在创新，但在其常规使用成为现实之前，需要解决毒性和成本等问题。
