凝集素靶向M细胞：一种黏膜疫苗接种和药物递送策略。

M cell targeting by lectins: a strategy for mucosal vaccination and drug delivery.

作者信息

Jepson Mark A, Clark M Ann, Hirst Barry H

机构信息

Cell Imaging Facility and Department of Biochemistry, School of Medical Sciences, University of Bristol, Bristol BS8 1TD, UK.

出版信息

Adv Drug Deliv Rev. 2004 Mar 3;56(4):511-25. doi: 10.1016/j.addr.2003.10.018.

DOI:10.1016/j.addr.2003.10.018

PMID:14969756

Abstract

Bioadhesins are a recognised method of enhancing the absorption of drugs and vaccines at mucosal surfaces. Additionally, bioadhesins allow for cell specific targeting. Lectin-mediated targeting and delivery exploits unique surface carbohydrates on mucosal epithelial cells. The antigen-sampling M cells offer a portal for absorption of colloidal and particulate delivery vehicles, including bacteria, viruses and inert microparticles. We review work supporting the use of lectins to aid targeting to intestinal M cells. Consideration is also given to lectin-mediated targeting in non-intestinal sites and to the potential application of other bioadhesins to enhance M cell transport. While substantial hurdles must be overcome before mucosal bioadhesins can guarantee consistent, safe, effective mucosal delivery, this strategy offers novel opportunities for drug and vaccine formulation.

摘要

生物黏附剂是一种公认的增强药物和疫苗在黏膜表面吸收的方法。此外，生物黏附剂能够实现细胞特异性靶向。凝集素介导的靶向和递送利用了黏膜上皮细胞上独特的表面碳水化合物。抗原采样M细胞为包括细菌、病毒和惰性微粒在内的胶体和颗粒递送载体的吸收提供了一个入口。我们综述了支持使用凝集素辅助靶向肠道M细胞的研究工作。同时也考虑了凝集素在非肠道部位的介导靶向作用以及其他生物黏附剂增强M细胞转运的潜在应用。虽然在黏膜生物黏附剂能够保证持续、安全、有效地进行黏膜递送之前，还必须克服诸多障碍，但这一策略为药物和疫苗制剂提供了新的机遇。