大家庭中多位点DNA指纹的似然性。
Likelihoods of multilocus DNA fingerprints in extended families.
作者信息
Bockel B, Nürnberg P, Krawczak M
机构信息
Institut für Humangenetik, Göttingen, Germany.
出版信息
Am J Hum Genet. 1992 Sep;51(3):554-61.
A concept for the application of complex pedigree analysis to multilocus DNA fingerprinting is described. By following this approach, the extent to which the DNA fingerprints of grandparents influence the phenotype likelihoods of their offspring was determined. It was demonstrated by simulation that approximately 90% of paternity disputes can be solved if mother, child, and paternal grandparents, instead of the putative father, are tested. If only phenotype information on a single paternal sib is allowed for, true paternity will be detected with reasonable persuasive power in up to 64% of cases. Exclusion of false paternity remains possible for 40% of cases. Finally, the analysis concept is modified by reducing the number of genotype variations considered in likelihood computations. This time-saving procedure is shown to yield sufficiently accurate likelihoods in the analysis of both simulation data and multilocus DNA fingerprints obtained in two large families.
本文描述了一种将复杂系谱分析应用于多位点DNA指纹识别的概念。通过采用这种方法，确定了祖父母的DNA指纹对其后代表型可能性的影响程度。模拟结果表明，如果对母亲、孩子和祖父母（而非推定父亲）进行检测，大约90%的亲子关系纠纷可以得到解决。如果仅允许使用单个父系同胞的表型信息，在高达64%的案例中，将以合理的说服力检测到真实的亲子关系。40%的案例仍有可能排除错误的亲子关系。最后，通过减少似然计算中考虑的基因型变异数量对分析概念进行了修改。结果表明，这种节省时间的方法在分析模拟数据和两个大家庭获得的多位点DNA指纹时，能够产生足够准确的似然值。
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