Krawczak M, Lubjuhn T
Institut für Humangenetik, Medizinische Hochschule, Hannover, Germany.
Electrophoresis. 1995 Jan;16(1):16-21. doi: 10.1002/elps.1150160105.
An informativity index for multilocus DNA fingerprints, r, was developed. It is based upon the Shannon information that a paternal DNA fingerprint conveys about the offspring phenotype pattern. Both simulation and empirical data reveal that the index r is strongly correlated with the mean log likelihood ratio (paternity vs. nonpaternity) expected in trio cases of true paternity. Since r can be estimated from DNA fingerprints of unrelated individuals in advance, it will provide an easy means to assess the potential utility of a given probe/enzyme combination in kinship testing.
开发了一种多位点DNA指纹信息指数r。它基于父系DNA指纹所传达的关于后代表型模式的香农信息。模拟和实证数据均表明，指数r与真实父系三联体案例中预期的平均对数似然比（父系与非父系）密切相关。由于r可以预先从无关个体的DNA指纹中估计出来，它将为评估给定探针/酶组合在亲缘关系测试中的潜在效用提供一种简便方法。
