阿米替林缓解截肢者疼痛的试验：一项随机对照研究的结果
Trial of amitriptyline for relief of pain in amputees: results of a randomized controlled study.
作者信息
Robinson Lawrence R, Czerniecki Joseph M, Ehde Dawn M, Edwards W Thomas, Judish David A, Goldberg Myron L, Campbell Kellye M, Smith Douglas G, Jensen Mark P
机构信息
Department of Rehabilitation Medicine, University of Washington, Seattle 98104, USA.
出版信息
Arch Phys Med Rehabil. 2004 Jan;85(1):1-6. doi: 10.1016/s0003-9993(03)00476-3.
OBJECTIVE
To evaluate whether amitriptyline is more effective than placebo in improving phantom limb pain or residual limb pain.
DESIGN
Randomized controlled trial of amitriptyline for 6 weeks.
SETTING
University hospital.
PARTICIPANTS
Thirty-nine persons with amputation-related pain lasting more than 6 months.
INTERVENTION
Six-week trial of amitriptyline (titrated up to 125 mg/d) or an active placebo (benztropine mesylate).
MAIN OUTCOME MEASURES
Analyses were conducted to examine whether there was a medication group effect on the primary outcomes (average pain intensity) and secondary outcome measures (disability, satisfaction with life, handicap).
RESULTS
No significant differences were found between the treatment groups in outcome variables when controlling for initial pain scores.
CONCLUSIONS
Our findings do not support the use of amitriptyline in the treatment of postamputation pain.
目的
评估阿米替林在改善幻肢痛或残肢痛方面是否比安慰剂更有效。
设计
阿米替林为期6周的随机对照试验。
地点
大学医院。
参与者
39名与截肢相关疼痛持续超过6个月的患者。
干预措施
为期6周的阿米替林试验（滴定至125毫克/天）或活性安慰剂（甲磺酸苯扎托品）。
主要结局指标
进行分析以检查药物治疗组对主要结局（平均疼痛强度）和次要结局指标（残疾、生活满意度、残障）是否有影响。
结果
在控制初始疼痛评分时，治疗组之间在结局变量上未发现显著差异。
结论
我们的研究结果不支持使用阿米替林治疗截肢后疼痛。
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