再生周围神经接口可有效预防大鼠坐骨神经横断后神经瘤的形成。
Regenerative Peripheral Nerve Interfaces Effectively Prevent Neuroma Formation After Sciatic Nerve Transection in Rats.
作者信息
Wu Jiaqing, Zhang Yajun, Zhang Xiaoyuan, Lin Zhiyu, Li Guangxue
机构信息
Department of Plastic Surgery, Peking University People's Hospital, Beijing, China.
Trauma Medicine Center, Peking University People's Hospital, Beijing, China.
出版信息
Front Mol Neurosci. 2022 Jul 7;15:938930. doi: 10.3389/fnmol.2022.938930. eCollection 2022.
OBJECTIVE
The disordered growth of nerve stumps after amputation leading to the formation of neuromas is an important cause of postoperative pain in amputees. This severely affects the patients' quality of life. Regenerative peripheral nerve interfaces (RPNIs) are an emerging method for neuroma prevention, but its postoperative nerve growth and pathological changes are yet to be studied.
METHODS
The rat sciatic nerve transection model was used to study the effectiveness of RPNI in this experiment. The RPNI (experimental) group ( = 11) underwent RPNI implantation after sciatic nerve transection, while the control group ( = 11) only underwent sciatic nerve transection. Autotomy behavior, ultrasonography, and histopathology were observed for 2 months postoperatively.
RESULTS
Compared to the control group, the incidence and size of the neuromas formed and the incidence and extent of autotomy were significantly reduced in the RPNI group. The axon density in the stump and degree of stump fibrosis were also significantly reduced in the RPNI group.
CONCLUSION
RPNI effectively prevented the formation of neuromas.
目的
截肢后神经残端无序生长导致神经瘤形成是截肢者术后疼痛的重要原因。这严重影响患者生活质量。再生周围神经接口（RPNI）是一种新兴的预防神经瘤的方法，但其术后神经生长及病理变化尚待研究。
方法
本实验采用大鼠坐骨神经横断模型研究RPNI的有效性。RPNI（实验组）（n = 11）在坐骨神经横断后行RPNI植入，而对照组（n = 11）仅行坐骨神经横断。术后2个月观察自残行为、超声检查及组织病理学情况。
结果
与对照组相比，RPNI组神经瘤形成的发生率和大小以及自残的发生率和程度均显著降低。RPNI组残端的轴突密度和残端纤维化程度也显著降低。
结论
RPNI能有效预防神经瘤形成。
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