Leonard Stephen S, Bower Jacquelyn J, Shi Xianglin
Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV 26505, USA.
Mol Cell Biochem. 2004 Jan;255(1-2):3-10. doi: 10.1023/b:mcbi.0000007255.72746.a6.
A wide variety of metals have been reported to act as mutagenic and carcinogenic agents in both human and animal studies. The underlying mechanisms are being extensively investigated. Recently, a new sub-discipline of molecular carcinogenesis has surfaced and new techniques and instruments are being developed which allow exploration of the complex biological relationships and signaling pathways involved in response to metal exposure at the molecular level. The 2nd Conference on Molecular Mechanisms of Metal Toxicity and Carcinogenesis was held at NIOSH in Morgantown, West Virginia, Sept. 8-11, 2002. One hundred thirty scientist from sixteen countries presented their novel findings and investigations of metal-induced carcinogenesis. The conference focused on state-of-the-art research and developments in metal toxicity and carcinogenesis. Emphasis was placed on delineating molecular mechanisms involved in free radical effects, cellular uptake, signaling pathways/interaction, dose response, biomarkers, and resistance mechanisms. This article reviews some of the novel information presented at the conference and discusses future avenues of research in this field.
在人体和动物研究中，已有大量金属被报告为诱变剂和致癌剂。其潜在机制正在被广泛研究。最近，分子致癌作用这一新的子学科已经出现，并且正在开发新的技术和仪器，以便在分子水平上探索与金属暴露反应相关的复杂生物关系和信号通路。2002年9月8日至11日，第二届金属毒性与致癌作用分子机制会议在西弗吉尼亚州摩根敦的美国国家职业安全与健康研究所举行。来自16个国家的130位科学家展示了他们关于金属诱导致癌作用的新发现和研究成果。会议聚焦于金属毒性和致癌作用的前沿研究与进展。重点在于描绘自由基效应、细胞摄取、信号通路/相互作用、剂量反应、生物标志物以及抗性机制等方面涉及的分子机制。本文回顾了会议上展示的一些新信息，并讨论了该领域未来的研究方向。
