在兔模型中比较Sepramesh与Dualmesh用于腹壁疝修补的效果

Sepramesh vs. Dualmesh for abdominal wall hernia repairs in a rabbit model.

作者信息

Young Ricardo M, Gustafson Robert, Dinsmore Robert C

机构信息

Departments of Surgety and Clinical Investigation, Eisenhower Army Medical Center, Fort Gordon, Georgia 30905, USA.

出版信息

Curr Surg. 2004 Jan-Feb;61(1):77-9. doi: 10.1016/j.cursur.2003.09.011.

DOI:10.1016/j.cursur.2003.09.011

PMID:14972176

Abstract

PURPOSE

To compare the relative strength of incorporation and adhesion formation for mesh hernia repairs performed with Sepramesh (Genzyme Corp., Cambridge, Massachusetts) and Dualmesh (WL Gore and Assoc., Flagstaff, Arizona).

METHODS

A prospective randomized study was conducted using 30 New Zealand white rabbits, with 15 animals randomized to each limb. A standardized abdominal defect was created in each animal. The defect was then repaired using either Sepramesh or Dualmesh. Animals were sacrificed at 4 weeks. The area of adhesions was determined using digital analysis of inked specimens. Strength of incorporation was determined using an Instron Tensiometer. (Department of Clinical Research, D. D. Eisenhower Army Medical Center, Fort Gordon, GA 30905.)

RESULTS

Sepramesh had a 30.6% stronger strength of incorporation compared with Dualmesh. (p = 0.011) The difference in area of adhesions was not statistically significant between the 2 products.

CONCLUSIONS

The use of Sepramesh for abdominal hernia repairs provides a significantly stronger strength of incorporation without increasing the amount of adhesions as compared with Dualmesh.

摘要

目的

比较使用Sepramesh（健赞公司，马萨诸塞州剑桥）和Dualmesh（WL戈尔公司，亚利桑那州弗拉格斯塔夫）进行疝修补术时补片植入强度和粘连形成的相对强度。

方法

对30只新西兰白兔进行前瞻性随机研究，每组15只动物。在每只动物身上制造一个标准化的腹部缺损。然后使用Sepramesh或Dualmesh修复缺损。4周后处死动物。通过对染色标本进行数字分析确定粘连面积。使用英斯特朗拉力试验机测定植入强度。（佐治亚州戈登堡市德怀特·D·艾森豪威尔陆军医疗中心临床研究部，邮编30905）