Department of General Surgery, Nigde State Hospital, Nigde, Turkey.
Hernia. 2013 Apr;17(2):249-53. doi: 10.1007/s10029-012-0979-1. Epub 2012 Aug 21.
The aim of this study was to determine the rate of collagen Type I/Type III for different meshes.
Fifty rats were used. Five groups were formed: prolene (n = 10), mersilene (n = 10), parietex (n = 10), e PTFE (n = 10) and control group (n = 10). In all animals, laparotomy was performed using a midline incision. After that four different kinds of meshes are placed into the retro-rectus plane and fixed with a non-absorbable suture. Rectus superficial fascia and skin are closed. In the control group, repairment is done primarily. Thirty days later, meshes are found through the incisions that were done previously. Scar tissues above and near by meshes and also in the control group are taken, and in these tissue samples, the ratio of Type I/III is evaluated histochemically.
The Prolene mesh was found to contain more collagen fibers than e PTFE. As a result of the histopathologic evaluation, it was seen that Group I contained statistically significantly more collagen density than the other four groups (p < 0.05). Moreover, the collagen Type I/III ratio in the specimen taken from the top part and the surrounding area of Group I was found significantly higher than the collagen Type I/III ratios of the rest of the groups (p < 0.05).
As a conclusion, the ratio of collagen Type I/III is the highest in the prolene group.
本研究旨在确定不同网片的 I 型/III 型胶原比率。
使用 50 只大鼠。分为 5 组：普理灵（n=10）、慕丝灵（n=10）、巴德补片（n=10）、ePTFE（n=10）和对照组（n=10）。所有动物均采用正中切口行剖腹术。然后将四种不同的网片置于后腹膜平面，用不可吸收缝线固定。缝合腹直肌浅筋膜和皮肤。在对照组中，进行一期修复。30 天后，通过之前做的切口找到网片。取网片上方和附近的瘢痕组织以及对照组的组织标本，用组织化学方法评估 I/III 型胶原的比值。
普理灵网片所含胶原纤维多于 ePTFE。组织病理学评估显示，第 I 组的胶原密度明显高于其他四组（p<0.05）。此外，第 I 组标本取自顶部和周围区域的 I/III 型胶原比值明显高于其余各组（p<0.05）。
总之，普理灵组的 I/III 型胶原比值最高。
