Lai Eric C
Howard Hughes Medical Institute, 545 Life Sciences Addition, Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720-3200, USA.
Development. 2004 Mar;131(5):965-73. doi: 10.1242/dev.01074.
Notch is a transmembrane receptor that mediates local cell-cell communication and coordinates a signaling cascade present in all animal species studied to date. Notch signaling is used widely to determine cell fates and to regulate pattern formation; its dysfunction results in a tremendous variety of developmental defects and adult pathologies. This primer describes the mechanism of Notch signal transduction and how it is used to control the formation of biological patterns.
Notch是一种跨膜受体，介导局部细胞间通讯，并协调至今所研究的所有动物物种中存在的信号级联反应。Notch信号广泛用于决定细胞命运和调节模式形成；其功能障碍会导致各种各样的发育缺陷和成人疾病。本入门介绍了Notch信号转导的机制及其如何用于控制生物模式的形成。
