Sivakumar Rooban, Aravaanan Arul Senghor Kadalangudi, Mohanakrishnan Vinodhini Vellore, Kumar Janardhanan
Department of Biochemistry, SRM Medical College Hospital and Research Centre, SRM Institute of Science and Technology, SRM Nagar, Kattankulathur - 603203, Kanchipuram, Chennai, Tamil Nadu, India.
Department of General Medicine, SRM Medical College Hospital and Research Centre, SRM Institute of Science and Technology, SRM Nagar, Kattankulathur - 603203, Kanchipuram, Chennai, Tamil Nadu, India.
Iran J Public Health. 2025 Apr;54(4):675-687. doi: 10.18502/ijph.v54i4.18407.
Adropin, a peptide hormone has role in various various physiological processes, including metabolic regulation and cardiovascular health. This systematic review aimed to synthesize findings from observational studies on the involvement of adropin in neurological disorders and cognitive performance.
An extensive literature search was conducted across PubMed, Scopus, Web of Science, Embase, CORE, and Google Scholar using terms such as "adropin," "Neurological Disorders," "cognitive function," "Alzheimer's disease," "Parkinson's disease," "cognition," and "brain function." Studies published from 2020 to 2024 were selected and reviewed. The search and selection process adhered to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Out of 127 screened articles, 5 met the inclusion criteria for this review.
The combined research findings suggest a consistent link between decreased adropin levels and a range of neurological disorders and cognitive impairments. In particular, reduced adropin levels were seen in individuals with dementia, cognitive impairment, bipolar disorder, Parkinson's disease, and multiple sclerosis. These findings highlight adropin's potential role in modulating neurological health and cognitive function.
This systematic review underscores the importance of adropin in neurological health and its potential as a therapeutic agent. Based on the observed connections, adropin might serve as a new focus for treating neurological disorders, prompting the need for more research and trials.
Adropin是一种肽类激素，在包括代谢调节和心血管健康在内的各种生理过程中发挥作用。本系统评价旨在综合观察性研究中有关Adropin参与神经疾病和认知表现的研究结果。
在PubMed、Scopus、Web of Science、Embase、CORE和谷歌学术上进行了广泛的文献检索，使用了“Adropin”、“神经疾病”、“认知功能”、“阿尔茨海默病”、“帕金森病”、“认知”和“脑功能”等术语。选择并审查了2020年至2024年发表的研究。检索和选择过程遵循系统评价和Meta分析的首选报告项目（PRISMA）指南。在127篇筛选文章中，有5篇符合本评价的纳入标准。
综合研究结果表明，Adropin水平降低与一系列神经疾病和认知障碍之间存在一致的联系。特别是，在患有痴呆症、认知障碍、双相情感障碍、帕金森病和多发性硬化症的个体中发现Adropin水平降低。这些发现突出了Adropin在调节神经健康和认知功能方面的潜在作用。
本系统评价强调了Adropin在神经健康中的重要性及其作为治疗剂的潜力。基于观察到的联系，Adropin可能成为治疗神经疾病的新焦点，这促使需要更多的研究和试验。
