Martinez Arias A
Department of Zoology, University of Cambridge, United Kingdom.
Int J Dev Biol. 1998;42(3):325-33.
A large number of observations suggest that, during Drosophila development there are close functional interactions between the activity of Notch receptor and that of a signaling molecule encoded by wingless gene. In this essay, I summarize these interactions and discuss the possibility that Wingless acts as a ligand for Notch as part of a switch that is iteratively involved in the assignation of cell fates during development.
大量观察结果表明，在果蝇发育过程中，Notch受体的活性与无翅基因编码的信号分子的活性之间存在密切的功能相互作用。在本文中，我总结了这些相互作用，并讨论了无翅作为Notch配体的可能性，它是发育过程中反复参与细胞命运分配的开关的一部分。
