弗雷明汉心脏研究中调整后收缩压的方差成分连锁分析。

Variance components linkage analysis for adjusted systolic blood pressure in the Framingham Heart Study.

作者信息

Byng Martyn C, Fisher Sheila A, Lewis Cathryn M, Whittaker John C

机构信息

Division of Genetics and Development, Guy's, King's and St, Thomas' School of Medicine, 8th Floor, Guy's Tower, Guy's Hospital, London, United Kingdom.

出版信息

BMC Genet. 2003 Dec 31;4 Suppl 1(Suppl 1):S4. doi: 10.1186/1471-2156-4-S1-S4.

DOI:10.1186/1471-2156-4-S1-S4

PMID:14975072

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1866475/

Abstract

We performed variance components linkage analysis in nuclear families from the Framingham Heart Study on nine phenotypes derived from systolic blood pressure (SBP). The phenotypes were the maximum and mean SBP, and SBP at age 40, each analyzed either uncorrected, or corrected using two subsets of epidemiological/clinical factors. Evidence for linkage to chromosome 8p was detected with all phenotypes except the uncorrected maximum SBP, suggesting this region harbors a gene contributing to variation in SBP.

摘要

我们对弗雷明汉心脏研究中的核心家庭进行了方差成分连锁分析，涉及从收缩压（SBP）得出的九种表型。这些表型包括SBP的最大值、平均值以及40岁时的SBP，每种表型分别进行未校正分析，或使用两组流行病学/临床因素进行校正分析。除了未校正的SBP最大值外，在所有表型中均检测到与8号染色体短臂连锁的证据，这表明该区域存在一个导致SBP变异的基因。