Wilson C A, Berkowitz B A, McCuen B W, Charles H C
Department of Ophthalmology, Duke University Medical Center, Durham, NC.
Arch Ophthalmol. 1992 Aug;110(8):1098-100. doi: 10.1001/archopht.1992.01080200078028.
We obtained oxygen measurements from a human eye that contained small preretinal droplets of perfluorotributylamine (FTBA) by using fluorine-19 magnetic resonance spectroscopy. These droplets were the remainder of a larger volume of FTBA that was used as an intraoperative retinal tamponade during retinal detachment repair. The spin-lattice relaxation rate ([T1]-1) of the FTBA fluorine nuclide was obtained that could then be related, by direct proportionality, to droplet PO2. With the patient in a supine position, the droplets could be positioned over the macula in the preretinal vitreous space, whereon the FTBA PO2 could be influenced by the preretinal oxygen concentration. Preretinal PO2 values, derived from magnetic resonance spectroscopy, were in the range of 6 to 9 mm Hg, although multiple components were identified that were suggestive of a heterogeneous distribution of PO2 values in the population of droplets. To our knowledge, this investigation is the first to demonstrate the feasibility of this approach to performing long-term, noninvasive preretinal oxygen measurements in the vitrectomized human eye by using small droplets of a liquid perfluorochemical.
我们通过使用氟 - 19磁共振波谱技术，从一只含有小的视网膜前全氟三丁胺（FTBA）液滴的人眼中获取了氧含量测量值。这些液滴是在视网膜脱离修复术中用作视网膜填塞物的较大体积FTBA的剩余部分。获得了FTBA氟核素的自旋 - 晶格弛豫率（[T1] - 1），然后通过直接比例关系将其与液滴的PO2相关联。患者仰卧时，液滴可位于视网膜前玻璃体腔的黄斑上方，此时FTBA的PO2会受到视网膜前氧浓度的影响。尽管鉴定出多种成分提示液滴群体中PO2值存在异质性分布，但通过磁共振波谱得出的视网膜前PO2值范围为6至9毫米汞柱。据我们所知，本研究首次证明了使用液态全氟化合物的小液滴在玻璃体切除的人眼中进行长期、非侵入性视网膜前氧测量这种方法的可行性。
