母乳对极低出生体重儿氧化DNA损伤的抑制作用。
Suppressive effects of breast milk on oxidative DNA damage in very low birthweight infants.
作者信息
Shoji H, Shimizu T, Shinohara K, Oguchi S, Shiga S, Yamashiro Y
机构信息
Department of Paediatrics, Juntendo University School of Medicine, Tokyo, Japan.
出版信息
Arch Dis Child Fetal Neonatal Ed. 2004 Mar;89(2):F136-8. doi: 10.1136/adc.2002.018390.
Abstract
BACKGROUND
Human milk contains many kinds of antioxidant and is considered to prevent diseases mediated by oxygen free radicals in very low birthweight (VLBW) infants.
AIMS
To examine the antioxidant effects of breast milk in VLBW infants by determining urinary 8-hydroxydeoxyguanosine (8-OHdG) excretion, which is known to be a non-invasive marker for in vivo oxidative DNA damage.
METHODS
Urinary 8-OHdG concentrations were measured in 15 breast fed and 14 formula fed VLBW infants at 2, 7, 14, and 28 days of age.
RESULTS
Urinary 8-OHdG excretion at 14 and 28 days of age was significantly lower than at 2 and 7 days of age in the breast fed group, and significantly lower than in the formula fed group.
CONCLUSION
This is the first direct evidence of the antioxidant action of human milk in VLBW infants.
摘要
背景
母乳含有多种抗氧化剂，被认为可预防极低出生体重（VLBW）婴儿中由氧自由基介导的疾病。
目的
通过测定尿8-羟基脱氧鸟苷（8-OHdG）排泄量来检测母乳对VLBW婴儿的抗氧化作用，已知8-OHdG排泄量是体内氧化性DNA损伤的一种非侵入性标志物。
方法
在15名母乳喂养和14名配方奶喂养的VLBW婴儿2、7、14和28日龄时测量尿8-OHdG浓度。
结果
母乳喂养组14和28日龄时的尿8-OHdG排泄量显著低于2和7日龄时，且显著低于配方奶喂养组。
结论
这是母乳对VLBW婴儿抗氧化作用的首个直接证据。
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Oxidative stress in very low birth weight infants as measured by urinary 8-OHdG.通过尿8-羟基脱氧鸟苷测量极低出生体重儿的氧化应激。
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