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本文引用的文献

1
Oxidative stress in very low birth weight infants as measured by urinary 8-OHdG.通过尿8-羟基脱氧鸟苷测量极低出生体重儿的氧化应激。
Free Radic Res. 2002 Feb;36(2):189-93. doi: 10.1080/10715760290006510.
2
Association of human milk feedings with a reduction in retinopathy of prematurity among very low birthweight infants.极低出生体重儿母乳喂养与早产儿视网膜病变减少之间的关联。
J Perinatol. 2001 Sep;21(6):356-62. doi: 10.1038/sj.jp.7210548.
3
Quantitative determination of urinary 8-hydroxydeoxyguanosine (8-OH-dg) by using ELISA.采用酶联免疫吸附测定法（ELISA）对尿8-羟基脱氧鸟苷（8-OH-dG）进行定量测定。
Res Commun Mol Pathol Pharmacol. 2000;107(1-2):39-44.
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Antioxidative factors in milk.牛奶中的抗氧化因子。
Br J Nutr. 2000 Nov;84 Suppl 1:S103-10. doi: 10.1017/s0007114500002324.
5
Protein carbonyls and lipid peroxidation products as oxidation markers in preterm infant plasma: associations with chronic lung disease and retinopathy and effects of selenium supplementation.蛋白质羰基和脂质过氧化产物作为早产儿血浆中的氧化标志物：与慢性肺病和视网膜病变的关联以及硒补充剂的影响。
Pediatr Res. 2000 Jul;48(1):84-90. doi: 10.1203/00006450-200007000-00015.
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Urinary 8-hydroxydeoxyguanosine in infants and children.
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Bronchopulmonary dysplasia and oxidative stress: are we closer to an understanding of the pathogenesis of BPD?
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Quantitative immunohistochemical determination of 8-hydroxy-2'-deoxyguanosine by a monoclonal antibody N45.1: its application to ferric nitrilotriacetate-induced renal carcinogenesis model.用单克隆抗体N45.1对8-羟基-2'-脱氧鸟苷进行定量免疫组织化学测定：其在次氮基三乙酸铁诱导的肾癌发生模型中的应用。
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The correlation of elevated levels of an index of lipid peroxidation (MDA-TBA) with adverse outcome in the very low birthweight infant.极低出生体重儿中脂质过氧化指标（丙二醛-硫代巴比妥酸反应物）水平升高与不良结局的相关性。
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Early production of macrophage inflammatory protein-1 alpha occurs in respiratory distress syndrome and is associated with poor outcome.
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母乳对极低出生体重儿氧化DNA损伤的抑制作用。

Suppressive effects of breast milk on oxidative DNA damage in very low birthweight infants.

作者信息

Shoji H, Shimizu T, Shinohara K, Oguchi S, Shiga S, Yamashiro Y

机构信息

Department of Paediatrics, Juntendo University School of Medicine, Tokyo, Japan.

出版信息

Arch Dis Child Fetal Neonatal Ed. 2004 Mar;89(2):F136-8. doi: 10.1136/adc.2002.018390.

DOI:10.1136/adc.2002.018390
PMID:14977897
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1756038/
Abstract

BACKGROUND

Human milk contains many kinds of antioxidant and is considered to prevent diseases mediated by oxygen free radicals in very low birthweight (VLBW) infants.

AIMS

To examine the antioxidant effects of breast milk in VLBW infants by determining urinary 8-hydroxydeoxyguanosine (8-OHdG) excretion, which is known to be a non-invasive marker for in vivo oxidative DNA damage.

METHODS

Urinary 8-OHdG concentrations were measured in 15 breast fed and 14 formula fed VLBW infants at 2, 7, 14, and 28 days of age.

RESULTS

Urinary 8-OHdG excretion at 14 and 28 days of age was significantly lower than at 2 and 7 days of age in the breast fed group, and significantly lower than in the formula fed group.

CONCLUSION

This is the first direct evidence of the antioxidant action of human milk in VLBW infants.

摘要

背景

母乳含有多种抗氧化剂，被认为可预防极低出生体重（VLBW）婴儿中由氧自由基介导的疾病。

目的

通过测定尿8-羟基脱氧鸟苷（8-OHdG）排泄量来检测母乳对VLBW婴儿的抗氧化作用，已知8-OHdG排泄量是体内氧化性DNA损伤的一种非侵入性标志物。

方法

在15名母乳喂养和14名配方奶喂养的VLBW婴儿2、7、14和28日龄时测量尿8-OHdG浓度。

结果

母乳喂养组14和28日龄时的尿8-OHdG排泄量显著低于2和7日龄时，且显著低于配方奶喂养组。

结论

这是母乳对VLBW婴儿抗氧化作用的首个直接证据。