Inder T E, Darlow B A, Sluis K B, Winterbourn C C, Graham P, Sanderson K J, Taylor B J
Department of Paediatrics, Christchurch School of Medicine, New Zealand.
Acta Paediatr. 1996 Sep;85(9):1116-22. doi: 10.1111/j.1651-2227.1996.tb14228.x.
The objective of this study was to examine the relationship between malondialdehyde-thiobarbituric acid (MDA-TBA) levels, as a measure of lipid peroxidation, in very low birthweight (VLBW) infants and outcome measures. A prospective observational longitudinal study was carried out in two level III neonatal units in the South Island of New Zealand measuring MDA-TBA levels in 61 VLBW infants in 1993. MDA-TBA levels were measured in (i) maternal plasma within 48 h of parturition, (ii) cord plasma, and (iii) infants' plasma at 2, 7, 14 and 28 days of age and correlated with antenatal and postnatal factors. Elevated levels of plasma MDA-TBA at 7 days were associated with adverse respiratory and ophthalmological outcome in the VLBW infants. Elevated MDA-TBA levels were measured at sample times close to the time of death in the infants who died. These results substantiate previously reported preliminary observations and support the hypothesis that oxidative injury, particularly within the first 7 days of life, is associated with the development of the long-term complications of the pre-term infant. MDA-TBA levels appear to be a useful measure to continue to explore the role of free radical mediated disease in the VLBW infant.
本研究的目的是探讨极低出生体重（VLBW）婴儿中作为脂质过氧化指标的丙二醛 - 硫代巴比妥酸（MDA - TBA）水平与预后指标之间的关系。1993年，在新西兰南岛的两个三级新生儿病房开展了一项前瞻性观察性纵向研究，对61名极低出生体重婴儿的MDA - TBA水平进行了测量。测量了（i）分娩后48小时内的母体血浆、（ii）脐带血浆以及（iii）婴儿出生后2天、7天、14天和28天时的血浆中的MDA - TBA水平，并将其与产前和产后因素进行关联分析。极低出生体重婴儿出生后7天时血浆MDA - TBA水平升高与不良呼吸和眼科预后相关。在死亡婴儿临近死亡时采集的样本中检测到MDA - TBA水平升高。这些结果证实了先前报道的初步观察结果，并支持了氧化损伤（尤其是在生命的前7天内）与早产儿长期并发症的发生相关的假说。MDA - TBA水平似乎是继续探索自由基介导的疾病在极低出生体重婴儿中作用的一项有用指标。
