高纯度维生素B2为脓毒症和脓毒性休克提供了一种有前景的治疗策略。
Highly purified vitamin B2 presents a promising therapeutic strategy for sepsis and septic shock.
作者信息
Toyosawa Toshio, Suzuki Mamoru, Kodama Kohtarou, Araki Seiichi
机构信息
Tsukuba Research Laboratories, Eisai Co., Ltd., Tsukuba, Ibaraki 300-2635, Japan.
出版信息
Infect Immun. 2004 Mar;72(3):1820-3. doi: 10.1128/IAI.72.3.1820-1823.2004.
Abstract
Highly purified vitamin B2 (riboflavin 5'-sodium phosphate; purity > 97%) treatment by intravenous infusion at doses above those used clinically to treat vitamin B2 deficiency showed therapeutic effects in mice not only in cases of endotoxin- and exotoxin-induced shock but also in cases of gram-negative and gram-positive bacterial infection even after the toxemia had already begun.
摘要
通过静脉输注高纯度维生素B2（核黄素5'-磷酸钠；纯度>97%）进行治疗，所用剂量高于临床上用于治疗维生素B2缺乏症的剂量，结果表明，在小鼠中，不仅对内毒素和外毒素诱导的休克有效，而且对革兰氏阴性和革兰氏阳性细菌感染也有效，即使在毒血症已经开始的情况下也是如此。
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