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高纯度维生素B2为脓毒症和脓毒性休克提供了一种有前景的治疗策略。

Highly purified vitamin B2 presents a promising therapeutic strategy for sepsis and septic shock.

作者信息

Toyosawa Toshio, Suzuki Mamoru, Kodama Kohtarou, Araki Seiichi

机构信息

Tsukuba Research Laboratories, Eisai Co., Ltd., Tsukuba, Ibaraki 300-2635, Japan.

出版信息

Infect Immun. 2004 Mar;72(3):1820-3. doi: 10.1128/IAI.72.3.1820-1823.2004.

DOI:10.1128/IAI.72.3.1820-1823.2004
PMID:14977995
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC356010/
Abstract

Highly purified vitamin B2 (riboflavin 5'-sodium phosphate; purity > 97%) treatment by intravenous infusion at doses above those used clinically to treat vitamin B2 deficiency showed therapeutic effects in mice not only in cases of endotoxin- and exotoxin-induced shock but also in cases of gram-negative and gram-positive bacterial infection even after the toxemia had already begun.

摘要

通过静脉输注高纯度维生素B2（核黄素5'-磷酸钠；纯度>97%）进行治疗，所用剂量高于临床上用于治疗维生素B2缺乏症的剂量，结果表明，在小鼠中，不仅对内毒素和外毒素诱导的休克有效，而且对革兰氏阴性和革兰氏阳性细菌感染也有效，即使在毒血症已经开始的情况下也是如此。

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Highly purified vitamin B2 presents a promising therapeutic strategy for sepsis and septic shock.高纯度维生素B2为脓毒症和脓毒性休克提供了一种有前景的治疗策略。
Infect Immun. 2004 Mar;72(3):1820-3. doi: 10.1128/IAI.72.3.1820-1823.2004.
2
Effects of intravenous infusion of highly purified vitamin B2 on lipopolysaccharide-induced shock and bacterial infection in mice.静脉输注高纯度维生素B2对小鼠脂多糖诱导的休克和细菌感染的影响。
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本文引用的文献

1
Such stuff as dreams are made on: mediator-directed therapy in sepsis.梦想由此而生：脓毒症的介质导向治疗
Nat Rev Drug Discov. 2003 May;2(5):391-405. doi: 10.1038/nrd1084.
2
The immunopathogenesis of sepsis.脓毒症的免疫发病机制。
Nature. 2002;420(6917):885-91. doi: 10.1038/nature01326.
3
Epidemiology of sepsis: an update.脓毒症流行病学：最新进展
Crit Care Med. 2001 Jul;29(7 Suppl):S109-16. doi: 10.1097/00003246-200107001-00035.
4
Pathophysiologic basis of sepsis: considerations for future strategies of intervention.脓毒症的病理生理基础：对未来干预策略的思考
Crit Care Med. 2000 Sep;28(9 Suppl):S4-8. doi: 10.1097/00003246-200009001-00002.
5
Proinflammatory cytokines.促炎细胞因子
Chest. 2000 Aug;118(2):503-8. doi: 10.1378/chest.118.2.503.
6
Confirmatory platelet-activating factor receptor antagonist trial in patients with severe gram-negative bacterial sepsis: a phase III, randomized, double-blind, placebo-controlled, multicenter trial. BN 52021 Sepsis Investigator Group.严重革兰氏阴性菌败血症患者血小板活化因子受体拮抗剂确证性试验：一项III期、随机、双盲、安慰剂对照、多中心试验。BN 52021败血症研究组。
Crit Care Med. 1998 Dec;26(12):1963-71. doi: 10.1097/00003246-199812000-00021.
7
Proinflammatory and anti-inflammatory cytokines as mediators in the pathogenesis of septic shock.促炎和抗炎细胞因子作为脓毒性休克发病机制中的介质。
Chest. 1997 Dec;112(6 Suppl):321S-329S. doi: 10.1378/chest.112.6_supplement.321s.
8
The effects of ibuprofen on the physiology and survival of patients with sepsis. The Ibuprofen in Sepsis Study Group.布洛芬对脓毒症患者生理机能及生存率的影响。脓毒症布洛芬研究小组。
N Engl J Med. 1997 Mar 27;336(13):912-8. doi: 10.1056/NEJM199703273361303.
9
Treatment of severe systemic inflammatory response syndrome and sepsis with a novel bradykinin antagonist, deltibant (CP-0127). Results of a randomized, double-blind, placebo-controlled trial. CP-0127 SIRS and Sepsis Study Group.用新型缓激肽拮抗剂德尔替班（CP-0127）治疗严重全身炎症反应综合征和脓毒症。一项随机、双盲、安慰剂对照试验的结果。CP-0127 SIRS和脓毒症研究组
JAMA. 1997 Feb 12;277(6):482-7.
10
Nitrite/nitrate oxide (NOx) and cytokine levels in patients with septic shock.脓毒性休克患者的亚硝酸盐/硝酸盐氧化物（NOx）和细胞因子水平
Res Commun Mol Pathol Pharmacol. 1996 Mar;91(3):347-56.