Storey Elsdon, Tuck Kate, Hester Robert, Hughes Andrew, Churchyard Andrew
Department of Medicine (Neuroscience), Monash University, Melbourne, Australia.
Mov Disord. 2004 Feb;19(2):190-2. doi: 10.1002/mds.10657.
We assessed the inter-rater reliability of the 100-point International Cooperative Ataxia Rating Scale (ICARS). Three neurologists independently rated videotaped ICARS examinations of 22 subjects with genetically determined ataxias (spinocerebellar ataxia [SCA] Type 1 in 11; SCA Type 2 in 1; Friedreich's ataxia in 10) and 4 controls. Scores on live ICARS assessment had ranged from 0 to 7 for controls and 11 to 74 for ataxic subjects (clinically very mildly affected to wheelchair-bound). Inter-rater correlation was very high for the total score (Kendall's omega 0.994, 95% confidence interval, 0.988-0.997), and high to very high for each component subscore (0.791 for speech to 0.994 for posture/gait). All correlations were significant at P < 0.00001. The ICARS exhibits very high inter-rater reliability even without prior observer standardisation and is sensitive to a range of ataxia severities from very mild to severe.
我们评估了100分制国际协作共济失调评定量表（ICARS）的评分者间信度。三位神经科医生独立对22例遗传性共济失调患者（11例1型脊髓小脑共济失调[SCA1]；1例2型脊髓小脑共济失调[SCA2]；10例弗里德赖希共济失调）和4例对照者的ICARS检查录像进行评分。对照者现场ICARS评估得分范围为0至7分，共济失调患者为11至74分（临床症状从非常轻微到需要轮椅辅助）。评分者间总分的相关性非常高（肯德尔ω系数为0.994，95%置信区间为0.988 - 0.997），各分量表得分的相关性高至极高（言语分量表为0.791，姿势/步态分量表为0.994）。所有相关性在P < 0.00001时均具有显著性。即使没有事先对观察者进行标准化，ICARS也表现出非常高的评分者间信度，并且对从非常轻微到严重的一系列共济失调严重程度都很敏感。
