Di Lorenzo L, Basso A, Pesola G, Balice M, Tempesta M, Lasorsa G, Speranza G, Soleo L
Dipartimento di Medicina Interna e di Medicina Pubblica, Sezione di Medicina del Lavoro, Università degli Studi di Bari.
G Ital Med Lav Ergon. 2003 Jul-Sep;25 Suppl(3):112-3.
The effects were studied on cardiovascular risk factors of occupational exposure to carbon disulfide (CS2) concentrations ranging from 0.05 to 1.60 mg/m3, 74 workers exposed (E) to CS2 and 79 non-exposed (NE) workers were examined. Information was obtained on age, working age and life habits (alcohol, smoke, etc.) through a questionnaire and height and weight were measured to assess body mass index (BMI). All the workers underwent blood collection for the assessment of total cholesterol, HDL cholesterol and triglyceride levels and electrocardiogram. No clinically evident heart disease were detected in the workers examined and the prevalences of obesity and hypertension resulted to be similar among workers of the two groups. Mean triglyceride levels and frequencies of hypertriglyceridemia and of HDL cholesterol values < 40 mg/dl were significantly higher in exposed workers than non-exposed. The triglyceride levels resulted to be significantly and directly influenced by BMI and exposure to CS2. Occupational exposure to low environmental CS2 concentrations seems to interacts with other factors to determine alterations of lipid metabolism.
研究了职业性接触浓度范围为0.05至1.60毫克/立方米的二硫化碳（CS2）对心血管危险因素的影响，对74名接触CS2的工人（E组）和79名未接触CS2的工人（NE组）进行了检查。通过问卷调查获取了年龄、工作年限和生活习惯（饮酒、吸烟等）的信息，并测量了身高和体重以评估体重指数（BMI）。所有工人均接受采血以评估总胆固醇、高密度脂蛋白胆固醇和甘油三酯水平以及心电图检查。在接受检查的工人中未检测到明显的临床心脏病，两组工人中肥胖和高血压的患病率相似。接触组工人的平均甘油三酯水平、高甘油三酯血症的频率以及高密度脂蛋白胆固醇值<40毫克/分升的频率均显著高于未接触组。甘油三酯水平受BMI和CS2接触的显著直接影响。职业性接触低环境浓度的CS2似乎与其他因素相互作用，导致脂质代谢改变。
