Craft Suzanne, Watson G Stennis
Geriatric Research, Education, and Clinical Center, Veterans Affairs Puget Sound Medical Center, Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, Seattle, 98108, USA.
Lancet Neurol. 2004 Mar;3(3):169-78. doi: 10.1016/S1474-4422(04)00681-7.
Insulin has functions in the brain and dysregulation of these functions may contribute to the expression of late-life neurodegenerative disease. We provide a brief summary of research on the influence of insulin on normal brain function. We then review evidence that perturbation of this role may contribute to the symptoms and pathogenesis of various neurodegenerative disorders, such as Alzheimer's disease, vascular dementia, Parkinson's disease, and Huntington's disease. We conclude by considering whether insulin dysregulation contributes to neurodegenerative disorders through disease-specific or general mechanisms.
胰岛素在大脑中发挥作用，这些功能的失调可能导致晚年神经退行性疾病的发生。我们简要总结了胰岛素对正常脑功能影响的研究。然后，我们回顾了相关证据，即这种作用的扰动可能导致各种神经退行性疾病的症状和发病机制，如阿尔茨海默病、血管性痴呆、帕金森病和亨廷顿病。我们通过思考胰岛素失调是通过疾病特异性机制还是一般机制导致神经退行性疾病来得出结论。
