氯胺 -T 介导的硫代糖苷在中性条件下化学选择性水解为糖基半缩醛。
Chloramine-T-mediated chemoselective hydrolysis of thioglycosides into glycosyl hemiacetals under neutral conditions.
作者信息
Misra Anup Kumar, Agnihotri Geetanjali
机构信息
Medicinal Chemistry Division, Central Drug Research Institute, Lucknow 226-001, India.
出版信息
Carbohydr Res. 2004 Mar 15;339(4):885-90. doi: 10.1016/j.carres.2003.12.020.
PMID:14980833
Abstract
A metal-free, mild, efficient and chemoselective hydrolysis of several thioalkylglycosides (1) into their corresponding 1-hydroxy sugars (2) using sodium N-chloro-p-toluenesulfonamide trihydrate (chloramine-T) without affecting other functional groups is reported.
摘要
据报道，使用三水合N-氯对甲苯磺酰胺（氯胺-T）可将几种硫代烷基糖苷（1）无金属、温和、高效且化学选择性地水解为相应的1-羟基糖（2），且不影响其他官能团。
Zotero 插件