中国人群中亚甲基四氢叶酸还原酶677C→T多态性与肺癌风险
The methylenetetrahydrofolate reductase 677C-->T polymorphism and lung cancer risk in a Chinese population.
作者信息
Jeng Yi-Lin, Wu Mei-Hsuan, Huang Han-Bin, Lin Wei-Yu, You San-Lin, Chu Tang-Yuan, Chen Chien-Jen, Sun Chien-An
机构信息
School of Public Health, National Defense Medical Center, No. 161, Section 6 Min-Chuan East Road, Taipei 114, Taiwan, Republic of China.
出版信息
Anticancer Res. 2003 Nov-Dec;23(6D):5149-52.
BACKGROUND
We examined the relationship of the MTHFR C677T genotype with the risk of lung cancer in a nested case-control study conducted in a cancer screening follow-up study in Taiwan.
MATERIALS AND METHODS
A total of 59 histologically confirmed lung cancer cases and 232 cancer-free controls were recruited between July 1990 and December 2000. The MTHFR C677T genotype was determined by a PCR-restriction fragment length polymorphism assay.
RESULTS
The MTHFR 677T variant genotype, including 677CT and 677TT, was observed in 39% of cases and 47% of controls. The resultant adjusted odds ratio (OR) was 0.71 (95% confidence interval [CI] = 0.39-1.30). The inverse association of the MTHFR 677T variant genotype with lung cancer risk was apparent in both smokers and nonsmokers.
CONCLUSION
These results suggest that the MTHFR 677T variant genotype reduces the risk of lung cancer. Larger studies incorporating dietary folate intake and the variant genotypes are needed to clarify our results.
背景
在台湾一项癌症筛查随访研究中开展的巢式病例对照研究中，我们探究了亚甲基四氢叶酸还原酶（MTHFR）C677T基因型与肺癌风险之间的关系。
材料与方法
1990年7月至2000年12月期间，共招募了59例经组织学确诊的肺癌病例和232例无癌对照。通过聚合酶链反应-限制性片段长度多态性分析确定MTHFR C677T基因型。
结果
在39%的病例和47%的对照中观察到MTHFR 677T变异基因型，包括677CT和677TT。调整后的比值比（OR）为0.71（95%置信区间[CI]=0.39-1.30）。MTHFR 677T变异基因型与肺癌风险之间的负相关在吸烟者和非吸烟者中均很明显。
结论
这些结果表明，MTHFR 677T变异基因型可降低肺癌风险。需要开展纳入膳食叶酸摄入量和变异基因型的更大规模研究来阐明我们的结果。
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