Zhang Xue-DE, Li Yan-Ting, Yang Shuan-Ying, Li Wei
Department of Respiratory Medicine, The Second Affiliated Hospital, Xi'an Jiaotong University, Xi'an, Shannxi 710004;
Department of Ultrasonography, Tongchuan City People's Hospital, Tongchuan, Shannxi 727000, P.R. China.
Biomed Rep. 2013 May;1(3):440-446. doi: 10.3892/br.2013.68. Epub 2013 Feb 25.
Lung cancer is the most frequently occurring type of cancer worldwide and the leading cause of cancer mortality. Environmental and genetic factors play important roles in lung carcinogenesis. The aim of this meta-analysis was to investigate the association between methylenetetrahydrofolate reductase (MTHFR) polymorphism and the risk of lung cancer in East Asian populations. Related articles were identified through searching literature databases, such as PubMed, EMBASE, Web of Science, Chinese Biomedicine and CNKI. The odds ratio (OR) values in those studies were incorporated by meta-analysis to assess lung cancer susceptibility associated with the MTHFR mutation genotype. The MTHFR C677TT genotype exhibited a significantly increased risk of lung cancer compared to the MTHFR 677CC/CT genotype (OR=1.24; 95% CI, 1.01-1.52). No relationship was identified between the other MTHFR C677T genetic models and the risk of lung cancer and there was no significantly increased risk of lung cancer in A1298C genetic models. In a subgroup of hospital-based controls, according to the source of controls, the C677TT genotype exhibited a significantly increased risk of lung cancer, compared to the C677CC genotype (OR=3.01; 95% CI, 1.07-8.46). In the stratified analysis, the study indicated that the MTHFR 677TT genotype was associated with a significant increase in the risk of lung squamous carcinoma (OR=1.53; 95% CI, 1.09-2.14), whereas no association was observed between the MTHFR C677TT genotype and the risk of lung adenocarcinoma. No association was observed between MTHFR C677TT polymorphism and the risk of lung cancer when smoking was considered. In conclusion, the meta-analysis results suggested that MTHFR C677T polymorphisms exhibit a significantly increased risk of lung cancer and that the MTHFR 677TT genotype is associated with a significantly increased risk of lung squamous carcinoma.
肺癌是全球最常见的癌症类型，也是癌症死亡的主要原因。环境和遗传因素在肺癌发生过程中起着重要作用。本荟萃分析的目的是研究东亚人群中亚甲基四氢叶酸还原酶（MTHFR）基因多态性与肺癌风险之间的关联。通过检索文献数据库，如PubMed、EMBASE、Web of Science、中国生物医学数据库和知网，确定相关文章。通过荟萃分析纳入这些研究中的比值比（OR）值，以评估与MTHFR突变基因型相关的肺癌易感性。与MTHFR 677CC/CT基因型相比，MTHFR C677TT基因型显示肺癌风险显著增加（OR = 1.24；95%可信区间，1.01 - 1.52）。未发现其他MTHFR C677T基因模型与肺癌风险之间存在关联，且在A1298C基因模型中肺癌风险也未显著增加。在基于医院的对照组亚组中，根据对照来源，与C677CC基因型相比，C677TT基因型显示肺癌风险显著增加（OR = 3.01；95%可信区间，1.07 - 8.46）。在分层分析中，该研究表明MTHFR 677TT基因型与肺鳞癌风险显著增加相关（OR = 1.53；95%可信区间，1.09 - 2.14），而未观察到MTHFR C677TT基因型与肺腺癌风险之间存在关联。考虑吸烟因素时，未观察到MTHFR C677TT基因多态性与肺癌风险之间存在关联。总之，荟萃分析结果表明，MTHFR C677T基因多态性显示肺癌风险显著增加，且MTHFR 677TT基因型与肺鳞癌风险显著增加相关。
