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SRL致病岛的分子流行病学

Molecular epidemiology of the SRL pathogenicity island.

作者信息

Turner Sally A, Luck Shelley N, Sakellaris Harry, Rajakumar Kumar, Adler Ben

机构信息

Bacterial Pathogenesis Research Group, Department of Microbiology, Monash University, Victoria 3800, Australia.

出版信息

Antimicrob Agents Chemother. 2003 Feb;47(2):727-34. doi: 10.1128/AAC.47.2.727-734.2003.

DOI:10.1128/AAC.47.2.727-734.2003
PMID:12543684
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC151756/
Abstract

The Shigella resistance locus (SRL), which is carried on the SRL pathogenicity island (PAI) in Shigella flexneri 2a YSH6000, mediates resistance to the antibiotics streptomycin, ampicillin, chloramphenicol, and tetracycline. In the present study, we investigated the distribution and structural variation of the SRL and the SRL PAI in 71 Shigella isolates and 28 other enteric pathogens by PCR and Southern analysis. The SRL and SRL-related loci, although absent from the other enteric pathogens evaluated in this study, were found to be present in a number of Shigella isolates. SRL PAI markers were also present in the majority of strains carrying the SRL and SRL-related loci. PCR linkage studies with six of these strains demonstrated that the SRL is carried on elements similar in structure and organization to the YSH6000 SRL PAI, consistent with the hypothesis that the SRL PAI may be involved in the spread of multiple-antibiotic resistance in these strains.

摘要

志贺氏菌抗性位点（SRL）位于福氏志贺氏菌2a YSH6000的SRL致病岛（PAI）上，介导对链霉素、氨苄青霉素、氯霉素和四环素的抗性。在本研究中，我们通过PCR和Southern分析调查了71株志贺氏菌分离株和28株其他肠道病原体中SRL和SRL PAI的分布及结构变异。本研究中评估的其他肠道病原体中不存在SRL和与SRL相关的位点，但在许多志贺氏菌分离株中发现了这些位点。携带SRL和与SRL相关位点的大多数菌株中也存在SRL PAI标记。对其中6株菌株进行的PCR连锁研究表明，SRL存在于结构和组织与YSH6000 SRL PAI相似的元件上，这与SRL PAI可能参与这些菌株多重抗生素抗性传播的假设一致。

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