Vera-Cabrera Lucio, Ochoa-Felix Elsa Y, Gonzalez Gloria, Tijerina Rolando, Choi Sung H, Welsh Oliverio
Laboratorio Interdisciplinario de Investigación Dermatológica, Servicio de Dermatología, Hospital Universitario, Nuevo León, México.
Antimicrob Agents Chemother. 2004 Mar;48(3):1037-9. doi: 10.1128/AAC.48.3.1037-1039.2004.
In this work, we studied the in vitro sensitivity of 24 strains of Actinomadura madurae to a new oxazolidinone (DA-7867), gatifloxacin, moxifloxacin, and garenoxacin by using a broth microdilution method. We observed that the A. madurae strains had a high level of sensitivity to all the antimicrobials tested. The most active drug was DA-7867, with a MIC at which 90% of the strains are inhibited (MIC(90)) of 0.125 micro g/ml and a MIC(50) of 0.06 micro g/ml.
在本研究中，我们采用肉汤微量稀释法研究了24株马杜拉放线菌对一种新型恶唑烷酮（DA - 7867）、加替沙星、莫西沙星和加雷沙星的体外敏感性。我们观察到，马杜拉放线菌菌株对所有测试抗菌药物均具有高度敏感性。活性最强的药物是DA - 7867，其90%菌株被抑制时的最低抑菌浓度（MIC(90)）为0.125μg/ml，50%菌株被抑制时的最低抑菌浓度（MIC(50)）为0.06μg/ml。
