Hoppe Camilla, Mølgaard Christian, Thomsen Birthe Lykke, Juul Anders, Michaelsen Kim Fleischer
Department of Human Nutrition and Centre for Advanced Food Studies, The Royal Veterinary and Agricultural University, Frederiksberg, Denmark.
Am J Clin Nutr. 2004 Mar;79(3):494-501. doi: 10.1093/ajcn/79.3.494.
During the complementary feeding period, infants shift from a daily protein intake (PI) of approximately 1 g/kg body wt to an intake 3-4 times as high. A high PI probably has both endocrine and physiologic effects and may increase the risk of obesity.
We examined the associations between PI in infancy and body size and composition in late childhood.
We conducted an observational cohort study of 142 Danish healthy term infants (63 boys) born during 1987-1988. At 9 mo of age, diet, weight, length, skinfold thicknesses, insulin-like growth factor I, and serum urea nitrogen were determined. At 10 y of age, 105 children (51 boys) participated in a follow-up study. Diet, weight, height, skinfold thicknesses, percentage of body fat (dual-energy X-ray absorptiometry), insulin-like growth factor I, and serum urea nitrogen were determined.
At 9 mo of age, PI (in g/d and percentage of energy) was strongly correlated with body size (length and weight) but not with measures of adiposity. PI at 9 mo of age was positively associated with height and weight but not with percentage of body fat at 10 y of age. Inclusion of parental body size in the models did not change the associations, but the significant associations were attenuated when body size at 9 mo of age was included.
PI in infancy seems to stimulate early growth. This might explain part of the association between early PI and body size at 10 y of age, but a continuous effect of protein on growth during childhood cannot be excluded. PI in infancy was not associated with any measure of body fat at 10 y of age.
在辅食添加期，婴儿每日蛋白质摄入量（PI）从约1克/千克体重转变为高3 - 4倍的摄入量。高蛋白摄入可能具有内分泌和生理效应，并可能增加肥胖风险。
我们研究了婴儿期蛋白质摄入量与儿童晚期身体大小和组成之间的关联。
我们对1987 - 1988年出生的142名丹麦健康足月儿（63名男孩）进行了一项观察性队列研究。在9月龄时，测定饮食、体重、身长、皮褶厚度、胰岛素样生长因子I和血清尿素氮。在10岁时，105名儿童（51名男孩）参与了一项随访研究。测定饮食、体重、身高、皮褶厚度、体脂百分比（双能X线吸收法）、胰岛素样生长因子I和血清尿素氮。
在9月龄时，蛋白质摄入量（以克/天和能量百分比表示）与身体大小（身长和体重）密切相关，但与肥胖指标无关。9月龄时的蛋白质摄入量与10岁时的身高和体重呈正相关，但与体脂百分比无关。在模型中纳入父母的身体大小并没有改变这种关联，但当纳入9月龄时的身体大小后，显著关联减弱。
婴儿期的蛋白质摄入似乎会刺激早期生长。这可能部分解释了早期蛋白质摄入与10岁时身体大小之间的关联，但不能排除蛋白质在儿童期对生长的持续影响。婴儿期的蛋白质摄入与10岁时的任何体脂指标均无关联。
