Gunnarsdottir I, Thorsdottir I
Unit for Nutrition Research, Landspitali-University Hospital & Department of Food Science, University of Iceland, Reykjavik, Iceland.
Int J Obes Relat Metab Disord. 2003 Dec;27(12):1523-7. doi: 10.1038/sj.ijo.0802438.
To assess the relationship between size and growth measurements in infancy to body mass index (BMI) at 6 y.
A longitudinal observation study on randomly chosen infants' growth and consumption in infancy. Follow-up until the age of 6 y.
A total of 90 children who were born healthy and full-term.
Weight and height were measured at maternity wards and healthcare centers in Iceland throughout infancy and at 6 y. Food records were made every month during infancy. At 2, 4, 6, 9 and 12 months, food was weighed to calculate food and nutrient intake.
Weight gain from birth to 12 months as a ratio of birth weight was positively related to BMI at the age of 6 y in both genders (B=2.9+/-1.0, P=0.008, and B=2.0+/-0.9, P=0.032 for boys and girls, respectively). Boys in the highest quartile of protein intake (E%) at the age of 9-12 months had significantly higher BMI (17.8+/-2.4 kg/m(2)) at 6 y than the lowest (15.6+/-1.0 kg/m(2), P=0.039) and the second lowest (15.3+/-0.8 kg/m(2), P=0.01) quartile. Energy intake was not different between groups. Together, weight gain at 0-12 months and protein intake at 9-12 months explained 50% of the variance in BMI among 6-y-old boys.
Rapid growth during the first year of life is associated with increased BMI at the age of 6 y in both genders. In boys, high intake of protein in infancy could also contribute to childhood obesity.
评估婴儿期的体格大小和生长指标与6岁时体重指数（BMI）之间的关系。
一项针对随机选取的婴儿在婴儿期生长及营养摄入情况的纵向观察研究。随访至6岁。
共90名健康足月出生的儿童。
在冰岛的产科病房和医疗保健中心，于婴儿期及6岁时测量体重和身高。婴儿期每月记录食物摄入情况。在2、4、6、9和12个月时，对食物进行称重以计算食物和营养摄入量。
出生至12个月的体重增加相对于出生体重的比例，在6岁时与男女两性的BMI均呈正相关（男孩B = 2.9 ± 1.0，P = 0.008；女孩B = 2.0 ± 0.9，P = 0.032）。9至12个月时蛋白质摄入量（E%）处于最高四分位数的男孩，6岁时的BMI（17.8 ± 2.4 kg/m²）显著高于最低四分位数（15.6 ± 1.0 kg/m²，P = 0.039）和第二低四分位数（15.3 ± 0.8 kg/m²，P = 0.01）的男孩。各群组间能量摄入量无差异。0至12个月时的体重增加以及9至12个月时的蛋白质摄入量共同解释了6岁男孩BMI变异的50%。
生命第一年的快速生长与6岁时男女两性BMI的增加相关。对于男孩，婴儿期高蛋白摄入也可能导致儿童期肥胖。
