Fenwick D C, Daniel R C
Department of Physiology and Pharmacology, University of Queensland, St Lucia, Australia.
Br Vet J. 1992 Jul-Aug;148(4):301-13. doi: 10.1016/0007-1935(92)90083-D.
Hypocalcaemia was induced in a group of five aged Merino ewes (with low erythrocyte potassium status) by the intravenous infusion of 4.7% Na2EDTA solution for 4 h daily on 3 consecutive days. A similar control group was infused with 5.0% dextrose solution (10 ml/h) for the same period. Blood samples were taken immediately before infusion each day, hourly for 7 h, then at 08:00 each morning for a further 5 d. Studies were made on the changes in plasma (P) Ca, PNa, PK, PMg, PProtein (PProt), P inorganic phosphorus (PiP), erythrocyte (E) Na, EK, EMg, PCVs, and mean corpuscular cell volumes (MCV). Significant decreases occurred in PiP concentrations but these were only temporary, which suggests that PiP is unlikely to be involved in the complications of prolonged hypocalcaemia. Significant prolonged decreases in PNa, PK and EK and significant prolonged increases in PCVs suggested that fluid replacement therapy supplemented with Na and K may be worthy of further study in the treatment of ruminants affected by apparent biochemical or physiological complications to prolonged hypocalcaemia.
通过连续3天每天静脉输注4.7%的乙二胺四乙酸二钠（Na2EDTA）溶液4小时，诱导一组5只老龄美利奴母羊（红细胞钾水平低）出现低钙血症。在同一时期，给一个类似的对照组输注5.0%的葡萄糖溶液（10毫升/小时）。每天在输注前立即采集血样，每小时采集一次，共采集7小时，然后在接下来的5天里每天早上8点采集血样。对血浆（P）钙、P钠、P钾、P镁、P蛋白（PProt）、P无机磷（PiP）、红细胞（E）钠、EK、E镁、红细胞压积（PCVs）和平均红细胞体积（MCV）的变化进行了研究。PiP浓度出现显著下降，但只是暂时的，这表明PiP不太可能参与长期低钙血症的并发症。P钠、P钾和EK显著长期下降，PCVs显著长期升高，这表明补充钠和钾的液体替代疗法在治疗受明显生化或生理并发症影响的反刍动物长期低钙血症方面可能值得进一步研究。
