Olin A-C, Alving K, Torén K
Department of Occupational and Environmental Medicine, Sahlgrenska University Hospital, Gothenburg, Sweden.
Clin Exp Allergy. 2004 Feb;34(2):221-6. doi: 10.1111/j.1365-2222.2004.01888.x.
Conflicting data have been presented as to whether nitric oxide (NO) in exhaled air is merely reflecting atopy rather than airway inflammation.
To investigate the relationship between exhaled NO (eNO) and nasal NO (nNO), respiratory symptoms, and atopy, in the context of a cross-sectional study of the respiratory health of bleachery workers.
Two hundred and forty-six non-smoking bleachery and paper-mill workers answered a questionnaire and were examined by measurements of eNO and nNO and spirometry, outside the pollen season. Blood samples were collected and analysed for specific IgE against common aeroallergens (birch, timothy, cat and house dust mite). Atopy was defined as a positive Phadiatop trade mark test.
The atopic and the non-atopic subjects without asthma or rhinitis had similar levels of eNO. Subjects reporting asthma or rhinitis who were also sensitized to perennial allergens had higher levels of eNO, whereas those sensitized to only seasonal allergens had similar eNO levels as non-atopic subjects with asthma or rhinitis. In multiple linear regression models adjusted for nNO, eNO was associated with asthma and sensitization to perennial allergens.
The results indicate that only atopic subjects who have recently been exposed to the relevant allergen have elevated levels of eNO. Atopic subjects who are not being exposed to a relevant allergen or have never experienced symptoms of asthma or rhinitis show normal eNO. These data indicate that eNO relates to airway inflammation in atopic subjects.
关于呼出气体中的一氧化氮（NO）仅仅是反映特应性而非气道炎症，已有相互矛盾的数据报道。
在一项对漂白厂工人呼吸健康的横断面研究中，调查呼出NO（eNO）与鼻腔NO（nNO）、呼吸道症状和特应性之间的关系。
246名不吸烟的漂白厂和造纸厂工人在花粉季节之外回答了一份问卷，并接受了eNO、nNO测量和肺活量测定检查。采集血样并分析针对常见气传变应原（桦树、梯牧草、猫和屋尘螨）的特异性IgE。特应性定义为Phadiatop商标试验阳性。
无哮喘或鼻炎的特应性和非特应性受试者的eNO水平相似。报告有哮喘或鼻炎且对常年性变应原致敏的受试者eNO水平较高，而仅对季节性变应原致敏的受试者的eNO水平与有哮喘或鼻炎的非特应性受试者相似。在根据nNO进行校正的多元线性回归模型中，eNO与哮喘和对常年性变应原的致敏相关。
结果表明，只有近期接触过相关变应原的特应性受试者的eNO水平升高。未接触相关变应原或从未经历过哮喘或鼻炎症状的特应性受试者的eNO水平正常。这些数据表明eNO与特应性受试者的气道炎症有关。
