Mehrparvar Amir Houshang, Ghanbari Laleh, Mirmohammadi Seyyed Jalil, Zare Sakhvidi Mohammad Javad, Vakili Mahmood, Davari Mohammad Hossein, Mirzaei Masoud
Industrial Diseases Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
Department of Occupational Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
Int J Prev Med. 2022 Apr 27;13:79. doi: 10.4103/ijpvm.IJPVM_546_20. eCollection 2022.
Fractional exhaled nitric oxide can be used as a biomarker of some respiratory diseases.
This study was conducted to compare exhaled nitric oxide in cigarette and water-pipe smokers with nonsmokers.
This cross-sectional study was conducted on 549 adult subjects as a sub-study of Shahedieh cohort in Yazd. Participants were divided into 5 groups according to their smoking habits: non-smokers ( = 202), cigarette smokers ( = 121), water-pipe smokers ( = 129), cigarette ex-smokers ( = 58), water-pipe and cigarette smokers ( = 39). The smokers were also categorized into heavy and light smokers. Fractional exhaled nitric oxide was compared between the groups.
The data were analyzed by SPSS (ver. 20) using Kolmogorov-Smirnov, Kruskal-Wallis, and Mann-Whitney tests.
Fractional exhaled NO was lower in all smokers than nonsmokers, but cigarette smokers showed the least level of NO than other groups. Fractional exhaled NO was not significantly lower in water-pipe smokers than nonsmokers.
Cigarette smoking significantly affect fractional exhaled NO, but water-pipe smoking did not significantly affect exhaled NO level.
呼出气一氧化氮分数可作为某些呼吸系统疾病的生物标志物。
本研究旨在比较吸烟者（吸卷烟和水烟者）与非吸烟者的呼出气一氧化氮水平。
本横断面研究作为亚兹德沙赫迪耶队列研究的一部分，对549名成年受试者进行。参与者根据吸烟习惯分为5组：非吸烟者（n = 202）、吸卷烟者（n = 121）、吸水烟者（n = 129）、既往吸卷烟者（n = 58）、既吸水烟又吸卷烟者（n = 39）。吸烟者还分为重度吸烟者和轻度吸烟者。比较各组间的呼出气一氧化氮分数。
使用SPSS（版本20）对数据进行分析，采用柯尔莫哥洛夫-斯米尔诺夫检验、克鲁斯卡尔-沃利斯检验和曼-惠特尼检验。
所有吸烟者的呼出气一氧化氮分数均低于非吸烟者，但吸卷烟者的一氧化氮水平低于其他组。吸水烟者的呼出气一氧化氮分数与非吸烟者相比无显著降低。
吸卷烟显著影响呼出气一氧化氮分数，但吸水烟对呼出气一氧化氮水平无显著影响。
