Lalonde Brendon R, Wallage H Rachelle
Centre of Forensic Sciences, Toxicology Section, 25 Grosvenor Street, 5th Floor, Toronto, Ontario, Canada, M7A 2G8.
J Anal Toxicol. 2004 Jan-Feb;28(1):71-4. doi: 10.1093/jat/28.1.71.
Despite the reported increased use of ketamine as a recreational drug, relatively few fatalities attributed to ketamine poisoning have been documented. Two recent fatalities in which ketamine was detected are described and compared with cases previously reported in the scientific literature. Concentrations of ketamine were measured in the heart and femoral blood samples using gas chromatography with nitrogen phosphorus detection. Ketamine concentrations in a 26-year-old man whose death was attributed to ketamine intoxication were 6.9 and 1.8 mg/L in heart and femoral blood, respectively. In this case, the ketamine concentration detected in the heart blood is in agreement with the lowest concentration reported in the literature, in which ketamine intoxication was ruled as the cause of death and no other drugs were present. Ketamine concentrations in a 20-year-old man, whose death was attributed to asthma and ketamine was considered an incidental finding, were 1.6 and 0.6 mg/L in heart and femoral blood, respectively. Marked differences between heart and femoral blood ketamine concentrations were observed in both of the reported cases. This may be indicative of incomplete distribution prior to death and/or postmortem redistribution of ketamine.
尽管有报道称氯胺酮作为娱乐性药物的使用有所增加，但记录在案的因氯胺酮中毒导致的死亡案例相对较少。本文描述了最近两例检测出氯胺酮的死亡案例，并与科学文献中先前报道的案例进行了比较。使用带氮磷检测的气相色谱法测量心脏和股血样本中的氯胺酮浓度。一名26岁男子因氯胺酮中毒死亡，其心脏血和股血中的氯胺酮浓度分别为6.9毫克/升和1.8毫克/升。在该案例中，心脏血中检测到的氯胺酮浓度与文献中报道的最低浓度一致，在该文献中，氯胺酮中毒被判定为死亡原因且未发现其他药物。一名20岁男子因哮喘死亡，氯胺酮被视为偶然发现，其心脏血和股血中的氯胺酮浓度分别为1.6毫克/升和0.6毫克/升。在这两例报道的案例中均观察到心脏血和股血中氯胺酮浓度存在显著差异。这可能表明死亡前分布不完全和/或氯胺酮的死后再分布。
