牛疱疹病毒1型潜伏相关基因的突变在病毒增殖性感染期间抑制开放阅读框2及相邻阅读框的蛋白表达。
A mutation in the latency-related gene of bovine herpesvirus 1 inhibits protein expression from open reading frame 2 and an adjacent reading frame during productive infection.
作者信息
Jiang Yunquan, Inman Melissa, Zhang Yange, Posadas Nuria Alemañ, Jones Clinton
机构信息
Department of Veterinary and Biomedical Sciences, Nebraska Center for Virology, University of Nebraska, Lincoln, Nebraska 68583-0905, Spain.
出版信息
J Virol. 2004 Mar;78(6):3184-9. doi: 10.1128/jvi.78.6.3184-3189.2004.
Abstract
The latency-related (LR) gene of bovine herpesvirus 1 (BHV-1) is abundantly expressed during latency. A mutant BHV-1 strain that contains three stop codons at the 5' terminus of the LR gene (LR mutant) does not reactivate from latency. This study demonstrates that the LR mutant does not express open reading frame 2 or an adjacent reading frame that lacks an initiating ATG (reading frame C). Since the LR mutant and wild-type BHV-1 express similar levels of LR RNA, we conclude that LR protein expression plays an important role in regulating the latency reactivation cycle in cattle.
摘要
牛疱疹病毒1型（BHV-1）的潜伏期相关（LR）基因在潜伏期间大量表达。一种在LR基因5'末端含有三个终止密码子的BHV-1突变株（LR突变体）不会从潜伏状态重新激活。本研究表明，LR突变体不表达开放阅读框2或缺乏起始ATG的相邻阅读框（阅读框C）。由于LR突变体和野生型BHV-1表达相似水平的LR RNA，我们得出结论，LR蛋白表达在调节牛的潜伏再激活周期中起重要作用。
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A mutation in the latency-related gene of bovine herpesvirus 1 inhibits protein expression from open reading frame 2 and an adjacent reading frame during productive infection.牛疱疹病毒1型潜伏相关基因的突变在病毒增殖性感染期间抑制开放阅读框2及相邻阅读框的蛋白表达。
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3
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Herpes simplex virus type 1 and bovine herpesvirus 1 latency.单纯疱疹病毒1型和牛疱疹病毒1型的潜伏感染
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