Galdiero M, Pisciotta M G, Marinelli A, Petrillo G, Galdiero E
Dipartimento di Medicina Sperimentale, Facoltd di Medicina e Chirurgia, Seconda Università di Napoli.
New Microbiol. 2002 Oct;25(4):427-36.
Viruses are thought to facilitate bacterial infections of the respiratory tract. The present study shows the effect of BHV-1 on Pasteurella multocida and Mannheimia haemolytica adherence and invasion of MDBK cells. The virus-infected MDBK cells become more susceptible to the adherence of both species of Pasteurella. The observed adherence increase depends on the length of virus pre-incubation time and on virus concentration. When MDBK cells are not infected with virus, they are only invaded by P. multocida, while M. haemolytica is not able to penetrate. The viral infection favours also the invasion by M. haemolytica.
病毒被认为会促进呼吸道的细菌感染。本研究显示了牛疱疹病毒1型（BHV - 1）对多杀性巴氏杆菌和溶血曼氏杆菌黏附及侵袭牛肾传代细胞（MDBK细胞）的影响。被病毒感染的MDBK细胞对两种巴氏杆菌的黏附变得更敏感。观察到的黏附增加取决于病毒预孵育时间的长短和病毒浓度。当MDBK细胞未被病毒感染时，它们仅被多杀性巴氏杆菌侵袭，而溶血曼氏杆菌无法穿透。病毒感染也有利于溶血曼氏杆菌的侵袭。
