Smye S W, Jollie M I, Cunliffe H, Littlewood J M
Department of Medical Physics, St James's University Hospital, Leeds, UK.
Clin Phys Physiol Meas. 1992 May;13(2):129-34. doi: 10.1088/0143-0815/13/2/004.
The evaporative losses of solvent (water) from a commercial jet nebuliser (Unineb, Unimed Ltd) were estimated and found to be approximately 14% of total nebuliser output. A simple analysis of the nebulisation process then enabled the amount of the drug colomycin released as potentially respirable aerosol to be predicted from measurements of the total nebulisation time. Good agreement was found between the predicted (P) and measured (M) values such that P = 1.07 M (r2 = 0.98). The analysis also indicates that the proportion of the drug released as aerosol will increase as nebulisation proceeds provided nebuliser output is continuous and that for a given initial mass of drug a larger amount of drug is released as an aerosol if the volume of administration used in the nebuliser is as large as possible.
对商用喷射雾化器（Unineb，Unimed有限公司）中溶剂（水）的蒸发损失进行了估算，发现其约占雾化器总输出量的14%。随后对雾化过程进行的简单分析，使得能够根据总雾化时间的测量结果预测作为潜在可吸入气雾剂释放的药物黏菌素的量。预测值（P）与测量值（M）之间具有良好的一致性，即P = 1.07M（r2 = 0.98）。该分析还表明，如果雾化器输出持续，随着雾化的进行，作为气雾剂释放的药物比例将会增加；并且对于给定初始质量的药物，如果雾化器中使用的给药体积尽可能大，则会有更多的药物作为气雾剂释放。
