O'Callaghan C, Clarke A R, Milner A D
Children's Respiratory Unit, University Hospital, Nottingham, United Kingdom.
Eur J Pediatr. 1989 Feb;148(5):473-4. doi: 10.1007/BF00595919.
A multistage liquid impinger was used to collect the nebulised cloud from three separate nebulisers. The output of sodium cromoglycate collected was determined by a spectrophotometric assay. Estimating drug output purely from weight loss during nebulisation resulted in a considerable overestimate compared with direct assay of the drug output from the nebulised cloud. During nebulisation, weight loss from the nebuliser occurs in the form of particle formation and also by evaporation. By only weighing the nebuliser chamber before and after nebulisation, weight loss due to evaporation is not taken into account and this is the cause of the overestimation of drug output by this method.
使用多级液体冲击器从三个独立的雾化器中收集雾化云。收集的色甘酸钠输出量通过分光光度法测定。与直接测定雾化云的药物输出量相比，仅根据雾化过程中的重量损失来估算药物输出量会导致相当大的高估。在雾化过程中，雾化器的重量损失以颗粒形成和蒸发的形式出现。仅在雾化前后对雾化器腔室进行称重，未考虑因蒸发导致的重量损失，这就是该方法高估药物输出量的原因。
