Lin Chun-Yu, Cheng Po-Hsu, Fang Sheen-Yie
Department of Otolaryngology, National Cheng Kung University Hospital, Tainan, Taiwan.
Ann Otol Rhinol Laryngol. 2004 Feb;113(2):147-51. doi: 10.1177/000348940411300213.
To evaluate the nasal mucosal changes in rhinitis medicamentosa (RM), especially those related to goblet cells and subepithelial glands, we studied specimens of the inferior turbinate mucosa from 8 patients with RM, 8 patients with chronic hypertrophic rhinitis (CHR), and 5 patients with normal nasal mucosa. All specimens were assessed by electron microscopy and immunohistochemical study. Under a scanning electron microscope, hyperplasia of goblet cells was most prominent in the RM group, and an increased number of gland openings was evident in the RM and CHR groups. In addition, the immunoreactivity of epidermal growth factor receptor staining was strongest in the hyperplastic epithelium of the RM group. According to our results, it is feasible that the mucosa of patients with RM is in a chronic inflammatory, hypersecretory state. Degenerative changes in the secretory elements may cause impairment of mucociliary transport and may be responsible for the nasal obstruction and posterior nasal drip in RM.
为评估药物性鼻炎（RM）的鼻黏膜变化，尤其是与杯状细胞和上皮下腺相关的变化，我们研究了8例RM患者、8例慢性肥厚性鼻炎（CHR）患者及5例正常鼻黏膜患者的下鼻甲黏膜标本。所有标本均通过电子显微镜和免疫组织化学研究进行评估。在扫描电子显微镜下，杯状细胞增生在RM组最为显著，RM组和CHR组的腺体开口数量均明显增加。此外，表皮生长因子受体染色的免疫反应性在RM组增生上皮中最强。根据我们的结果，RM患者的黏膜处于慢性炎症、高分泌状态是可行的。分泌成分的退行性变化可能导致黏液纤毛运输受损，并可能是RM患者鼻塞和鼻后滴漏的原因。
