Haeusler G, Schemper M, Frisch H, Blümel P, Schmitt K, Plöchl E
Department of Paediatrics, University Vienna, Austria.
Eur J Pediatr. 1992 Apr;151(4):283-7. doi: 10.1007/BF02072230.
Spontaneous growth of 141 untreated girls with Turner syndrome was analysed. Of the patients 25% were born prematurely; their weight and height were normal when compared to prematurely born healthy infants. However, birth weight and height was significantly retarded in Turner patients born at term. A curve for height and growth velocity for the age range 0-16 years was constructed with a sensitive statistical method. By use of a mathematical model equations were created for calculating z-scores and the related percentiles for the height of individual patients at given age. Median height of 18 untreated patients at 18 years was 143.8 cm. Analysis of growth velocity revealed a minor but significant growth spurt at the age of 12.5 years. This growth spurt was also detectable in patients without signs of spontaneous puberty and occurred later in patients with 45,X0 karyotype. Bone age progression was linear up to the age of 7.5 years and decelerated thereafter.
对141名未经治疗的特纳综合征女孩的自然生长情况进行了分析。其中25%的患者为早产儿；与早产的健康婴儿相比，她们的体重和身高正常。然而，足月出生的特纳综合征患者的出生体重和身高明显滞后。采用一种灵敏的统计方法构建了0至16岁年龄段的身高和生长速度曲线。通过使用数学模型创建了方程，用于计算特定年龄个体患者身高的z分数和相关百分位数。18名未经治疗的患者在18岁时的中位身高为143.8厘米。生长速度分析显示，在12.5岁时出现了轻微但显著的生长突增。这种生长突增在无自然青春期迹象的患者中也可检测到，且在核型为45,X0的患者中出现得更晚。骨龄进展在7.5岁之前呈线性，之后减速。
