Webster Daniel, Hill Adrian V S
Nuffield Department of Medicine, John Radcliffe Hospital, University of Oxford, Oxford, England.
Bull World Health Organ. 2003;81(12):902-9. Epub 2004 Mar 1.
Malaria is a parasitic disease of major global health significance that causes an estimated 2.7 million deaths each year. In this review we describe the burden of malaria and discuss the complicated life cycle of Plasmodium falciparum, the parasite responsible for most of the deaths from the disease, before reviewing the evidence that suggests that a malaria vaccine is an attainable goal. Significant advances have recently been made in vaccine science, and we review new vaccine technologies and the evaluation of candidate malaria vaccines in human and animal studies worldwide. Finally, we discuss the prospects for a malaria vaccine and the need for iterative vaccine development as well as potential hurdles to be overcome.
疟疾是一种具有重大全球健康意义的寄生虫病，每年估计导致270万人死亡。在本综述中，我们描述了疟疾的负担，并讨论了恶性疟原虫复杂的生命周期，该寄生虫导致了该疾病的大部分死亡，然后回顾了表明疟疾疫苗是一个可实现目标的证据。疫苗科学最近取得了重大进展，我们综述了新的疫苗技术以及全球范围内在人体和动物研究中对候选疟疾疫苗的评估。最后，我们讨论了疟疾疫苗的前景、迭代疫苗开发的必要性以及需要克服的潜在障碍。
