Hashimoto Masanori, Yokota Akira, Urasaki Eiichirou, Tsujigami Shuhji, Shimono Masayuki
Department of Neurosurgery, University of Occupational and Environmental Health, Iseigaoka 1-1, 807-8555 Yahata-Nishi, Kitakyushu, Japan.
Childs Nerv Syst. 2004 Oct;20(10):761-4. doi: 10.1007/s00381-003-0904-0. Epub 2004 Mar 4.
The authors present a case of a patient with an abdominal CSF pseudocyst that resulted from an allergic reaction to silicone. The patient underwent repair surgery of the meningomyelocele associated with the Chiari II malformation, and the V-P shunt was instituted at 6 months of age. A formation of the abdominal CSF pseudocyst and the consequent shunt malfunction were observed 40 days after the V-P shunt. An increase in the number of the peripheral eosinophils and serum immunoglobulin E (IgE), and an infiltration of eosinophils in the specimen harvested from the pseudocyst wall suggested an allergic reaction as the cause of the pseudocyst. A sixth operation to revise the V-P shunt was performed using the shunt system made of "extracted silicone", which was produced extracting the allergic substances.
The serum IgE was normalized after surgery and the abdominal CSF pseudocyst has not recurred for 22 months.
作者介绍了一例因对硅胶过敏反应导致腹部脑脊液假性囊肿的患者。该患者接受了与Chiari II型畸形相关的脊髓脊膜膨出修复手术,并在6个月大时植入了脑室-腹腔分流管。在脑室-腹腔分流术后40天观察到腹部脑脊液假性囊肿形成及随之而来的分流管功能障碍。外周嗜酸性粒细胞数量和血清免疫球蛋白E(IgE)增加,且从假性囊肿壁采集的标本中有嗜酸性粒细胞浸润,提示过敏反应是假性囊肿的病因。使用去除了过敏物质的“提取硅胶”制成的分流系统进行了第六次手术以修订脑室-腹腔分流管。
术后血清IgE恢复正常,腹部脑脊液假性囊肿22个月未复发。