中耳炎患儿对卡他莫拉菌外膜抗原的免疫反应。
Immune response to outer membrane antigens of Moraxella catarrhalis in children with otitis media.
作者信息
Faden H, Hong J, Murphy T
机构信息
Department of Pediatrics, State University of New York School of Medicine, Buffalo 14126.
出版信息
Infect Immun. 1992 Sep;60(9):3824-9. doi: 10.1128/iai.60.9.3824-3829.1992.
Abstract
The systemic and local antibody responses to homologous strains of Moraxella catarrhalis were investigated in 14 children with otitis media. A total of 8 children (57%) demonstrated a rise in serum antibody of the immunoglobulin G (IgG) (5 of 14), IgM (5 of 14), or IgA (6 of 14) classes of immunoglobulin to outer membrane antigens. Local antibody consisted of IgG (100%), IgM (29%), and IgA (71%). The IgG and IgA specific antibody present in middle-ear effusions appeared to represent local production rather than passive diffusion from the systemic circulation. These data suggest that young children develop an antibody response to M. catarrhalis in the middle ear during otitis media but fail to develop systemic antibody in a uniform manner.
摘要
对14名患有中耳炎的儿童针对卡他莫拉菌同源菌株的全身和局部抗体反应进行了研究。共有8名儿童（57%）的免疫球蛋白G（IgG）（14名中的5名）、IgM（14名中的5名）或IgA（14名中的6名）免疫球蛋白类别针对外膜抗原的血清抗体出现升高。局部抗体包括IgG（100%）、IgM（29%）和IgA（71%）。中耳积液中存在的IgG和IgA特异性抗体似乎代表局部产生，而非来自体循环的被动扩散。这些数据表明，幼儿在中耳炎期间中耳会对卡他莫拉菌产生抗体反应，但未能以统一方式产生全身抗体。
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