Jenkins J M, Davies D W, Anthony F, Wood P, Gadd S G, Watson R H, Masson G M
Department of Obstetrics and Gynaecology, University of Sheffield, Jessop Hospital for Women, UK.
Hum Reprod. 1992 Jul;7(6):776-80. doi: 10.1093/oxfordjournals.humrep.a137736.
Reviewing 780 in-vitro fertilization (IVF) cycles, where buserelin was commenced in the preceding luteal phase and human menopausal gonadotrophin on day 4 of the ensuing menses, 53 cycles were identified with sonolucent cysts (30-50 mm diameter). Of the latter 53 cycles, the serum oestradiol was significantly greater on day 4 in 22 cycles abandoned for poor follicular development than in 31 cycles which proceeded to oocyte retrieval (P less than 0.05). Of the 31 cycles proceeding to oocyte retrieval, nine had a day 4 serum oestradiol greater than 200 pmol/l (95th centile for day 4 oestradiol in patients without apparent cysts), and these cycles produced significantly fewer grade 1 embryos than the cycles with day 4 oestradiol levels less than or equal to 200 pmol/l (P less than 0.05). Six of the 53 cycles with cysts resulted in conception, and all of these cycles had a day 4 serum oestradiol less than 200 pmol/l. Among the 53 cycles with ovarian cysts, the serum progesterone on the day of abandonment in four cycles and on the day of human chorionic gonadotrophin administration in one non-abandoned cycle, was above the range established for 104 cycles without cysts. No significant difference was seen in day 4 serum androstenedione levels, and the day 4 serum progesterone was less than 5 nmol/l in all but one patient. Functional activity of ovarian cysts is associated with an adverse influence on IVF cycles.
回顾780个体外受精（IVF）周期，这些周期中在黄体期开始使用布舍瑞林，并在随后月经周期的第4天开始使用人绝经期促性腺激素，其中53个周期发现有透亮囊肿（直径30 - 50毫米）。在这53个周期中，因卵泡发育不良而放弃的22个周期在第4天的血清雌二醇水平显著高于进行卵母细胞取卵的31个周期（P < 0.05）。在进行卵母细胞取卵的31个周期中，有9个周期第4天的血清雌二醇水平高于200 pmol/l（无明显囊肿患者第4天雌二醇水平的第95百分位数），与第4天雌二醇水平小于或等于200 pmol/l的周期相比，这些周期产生的1级胚胎明显更少（P < 0.05）。53个有囊肿的周期中有6个周期成功受孕，并且所有这些周期第4天的血清雌二醇水平均小于200 pmol/l。在53个有卵巢囊肿的周期中，4个放弃周期在放弃当天以及1个未放弃周期在注射人绒毛膜促性腺激素当天的血清孕酮水平高于104个无囊肿周期所确定的范围。第4天血清雄烯二酮水平未见显著差异，除1例患者外，所有患者第4天的血清孕酮水平均小于5 nmol/l。卵巢囊肿的功能活性对IVF周期有不利影响。
