识别转录靶点。
Identifying transcriptional targets.
作者信息
Taverner Nicola V, Smith James C, Wardle Fiona C
机构信息
Wellcome Trust/Cancer Research UK Gurdon Institute and Department of Zoology, University of Cambridge, Cambridge CB2 1QR, UK.
出版信息
Genome Biol. 2004;5(3):210. doi: 10.1186/gb-2004-5-3-210. Epub 2004 Feb 27.
Abstract
Identifying the targets of transcription factors is important for understanding cellular processes. We review how targets have previously been isolated and outline new technologies that are being developed to identify novel direct targets, including chromatin immunoprecipitation combined with microarray screening and bioinformatic approaches.
摘要
确定转录因子的靶标对于理解细胞过程很重要。我们回顾了以前分离靶标的方法，并概述了正在开发的用于识别新的直接靶标的新技术，包括染色质免疫沉淀结合微阵列筛选和生物信息学方法。
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