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经皮肾镜取石术治疗小儿复杂性肾结石病

Percutaneous nephrolithotomy for complex pediatric renal calculus disease.

作者信息

Desai Mahesh R, Kukreja Rajesh A, Patel Snehal H, Bapat S D

机构信息

Department of Urology, Muljibhai Patel Urological Hospital, Gujarat, India.

出版信息

J Endourol. 2004 Feb;18(1):23-7. doi: 10.1089/089277904322836613.

Abstract

BACKGROUND AND PURPOSE

Pediatric renal calculus disease has been a management dilemma in view of the concern about the effects of the various treatment modalities on the growing kidney, the significant recurrence rate, and the long-term outcome. We report our experience with percutaneous nephrolithotomy (PCNL) monotherapy in staghorn or complex pediatric renal calculi.

PATIENTS AND METHODS

We retrospectively analyzed the case records of 116 patients younger than 15 years who underwent PCNL. The stones included 56 complex calculi. We defined complex calculi as either staghorn (complete or partial) or those with a large bulk and involving more than one calix, the upper ureter, or both.

RESULTS

Complete clearance was achieved in 50 patients (89.8%). Of these, 22 (39%) required a single tract, while 34 (61%) required multiple tracts. With subsequent SWL, the clearance rate increased to 96%. The average hemoglobin drop was 1.9 g/dL. Assessing the factors affecting the hemoglobin drop, the number of tracts and the size of tracts were found to be significant (P<0.01). The average change in the serum creatinine concentration between the preoperative and postoperative measurements was +0.03 mg/dL and was not different in patients with a single tract and those with multiple tracts (+0.02 and +0.04 mg/dL, respectively; P=NS). Intravenous urography done in 36 renal units postoperatively revealed good function in all. A DMSA renal scan in six children showed no scar.

CONCLUSIONS

Monotherapy with PCNL is safe and effective in the management of staghorn and complex renal calculi in single hospital stay. Ultrasound-guided peripheral caliceal puncture and limiting the tract dilatation to 22F are important factors in reducing the blood loss. Multiple tracts increase the hemoglobin drop but are not associated with an increased risk of complications (bleeding, postoperative infection, and prolonged urinary leak). Also, there is no deterioration in renal function after either single- or multiple-tract PCNL.

摘要

背景与目的

鉴于各种治疗方式对生长中的肾脏的影响、较高的复发率以及长期预后等问题,小儿肾结石病一直是治疗上的难题。我们报告了我们在鹿角形或复杂性小儿肾结石经皮肾镜取石术(PCNL)单一疗法方面的经验。

患者与方法

我们回顾性分析了116例15岁以下接受PCNL治疗患者的病例记录。结石包括56例复杂性结石。我们将复杂性结石定义为鹿角形(完全或部分)结石,或体积较大且累及一个以上肾盏、上段输尿管或两者的结石。

结果

50例患者(89.8%)实现了结石完全清除。其中,22例(39%)需要单通道,而34例(61%)需要多通道。随后进行体外冲击波碎石术(SWL)后,清除率提高到96%。平均血红蛋白下降1.9 g/dL。评估影响血红蛋白下降的因素时,发现通道数量和通道大小具有显著意义(P<0.01)。术前和术后血清肌酐浓度的平均变化为+0.03 mg/dL,单通道患者和多通道患者之间无差异(分别为+0.02和+0.04 mg/dL;P=无显著性差异)。术后对36个肾单位进行的静脉肾盂造影显示所有肾单位功能良好。对6名儿童进行的二巯基丁二酸(DMSA)肾扫描未显示瘢痕。

结论

在单次住院期间,PCNL单一疗法治疗鹿角形和复杂性肾结石是安全有效的。超声引导下外周肾盏穿刺以及将通道扩张限制在22F是减少失血的重要因素。多通道会增加血红蛋白下降,但与并发症(出血、术后感染和长期尿漏)风险增加无关。此外,单通道或多通道PCNL术后肾功能均无恶化。

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