S100A4表达与口腔鳞状细胞癌侵袭和转移的相关性
Correlation of S100A4 expression with invasion and metastasis in oral squamous cell carcinoma.
作者信息
Moriyama-Kita Makiko, Endo Yoshio, Yonemura Yutaka, Heizmann Claus W, Schäfer Beat W, Sasaki Takuma, Yamamoto Etsuhide
机构信息
Department of Experimental Therapeutics, Cancer Research Institute, Kanazawa University, 13-1 Takaramachi, Kanazawa 920-0934, Japan.
出版信息
Oral Oncol. 2004 May;40(5):496-500. doi: 10.1016/j.oraloncology.2003.10.003.
S100A4 is known to be involved in cancer cell motility by virtue of its ability to activate non-muscle myosin. In the current study, we investigated the interrelationship of clinico-pathological findings and S100A4 expression in oral squamous cell carcinoma (SCC). The expression of S100A4 was examined immunohistochemically in 41 clinical specimens of oral SCC. S100A4 expression was detected in 11 (26.8%) of 41 cases. Although the expression of S100A4 was not associated with the primary tumor site and degree of differentiation, there was a significant correlation between the increased S100A4-expression and the mode of invasion (p < 0.0001). In addition, the S100A4 status showed a clear correlation with lymph node metastasis (P < 0.01). These results lead us to conclude that S100A4 expression status may be a useful prognostic factor in patients with invasive and metastatic oral SCCs.
已知S100A4因其激活非肌肉肌球蛋白的能力而参与癌细胞的运动。在本研究中，我们调查了口腔鳞状细胞癌（SCC）临床病理结果与S100A4表达之间的相互关系。采用免疫组织化学方法检测了41例口腔SCC临床标本中S100A4的表达。41例中有11例（26.8%）检测到S100A4表达。虽然S100A4的表达与原发肿瘤部位和分化程度无关，但S100A4表达增加与侵袭方式之间存在显著相关性（p<0.0001）。此外，S100A4状态与淋巴结转移明显相关（P<0.01）。这些结果使我们得出结论，S100A4表达状态可能是侵袭性和转移性口腔SCC患者有用的预后因素。
Zotero 插件