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S100A4过表达作为口腔鳞状细胞癌转移和复发的生物标志物

Overexpression of S100A4 as a biomarker of metastasis and recurrence in oral squamous cell carcinoma.

作者信息

Natarajan Jayalakshmi, Hunter Keith, Mutalik Vimi S, Radhakrishnan Raghu

机构信息

Department of Oral Pathology and Microbiology, Manipal College of Dental Sciences, Manipal University, Manipal, India.

Department of Oral and Maxillofacial Pathology, University of Sheffield, Sheffield, UK.

出版信息

J Appl Oral Sci. 2014 Sep-Oct;22(5):426-33. doi: 10.1590/1678-775720140133.

DOI:10.1590/1678-775720140133
PMID:25466476
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4245755/
Abstract

UNLABELLED

S100A4, a biomarker of epithelial mesenchymal transition (EMT), plays an important role in invasion and metastasis by promoting cancer cell motility. In oral squamous cell carcinoma (OSCC), metastasis results in 90% of cancer associated mortality.

OBJECTIVE

To investigate the role of S100A4 expression as an important component of the epithelial mesenchymal transition (EMT) program in oral squamous cell carcinoma (OSCC).

MATERIAL AND METHODS

S100A4 protein expression was assessed semi-quantitatively by immunohistochemistry in 47 histologically confirmed cases of oral squamous cell carcinoma (OSCC) and 10 normal oral mucosal biopsies. The association between the S100A4 overexpression and the aggressive features of OSCC were analyzed by X2 test.

RESULTS

Moderate to strong cytoplasmic expression of S100A4 was observed in 30 out of 47 specimens of OSCC (64%). Overexpression of S100A4 was significantly associated with the clinical stage, lymph node involvement, metastases, pattern of invasion and recurrence (p<0.05).

CONCLUSION

S100A4 expression represents an important biomarker of prognostic significance that may be used to identify a subset of patients at high risk of invasion and metast.

摘要

未标记

S100A4是上皮-间质转化（EMT）的生物标志物，通过促进癌细胞迁移在侵袭和转移中起重要作用。在口腔鳞状细胞癌（OSCC）中，转移导致90%的癌症相关死亡。

目的

探讨S100A4表达作为上皮-间质转化（EMT）程序的重要组成部分在口腔鳞状细胞癌（OSCC）中的作用。

材料与方法

采用免疫组织化学半定量法检测47例经组织学确诊的口腔鳞状细胞癌（OSCC）和10例正常口腔黏膜活检组织中S100A4蛋白的表达。采用X2检验分析S100A4过表达与OSCC侵袭性特征之间的关系。

结果

47例OSCC标本中有30例（64%）观察到S100A4中度至强细胞质表达。S100A4过表达与临床分期、淋巴结受累、转移、侵袭模式和复发显著相关（p<0.05）。

结论

S100A4表达是一种具有预后意义的重要生物标志物，可用于识别侵袭和转移高危患者亚组。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f754/4245755/9bde4112a1c4/jaos-22-05-0426-g05.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f754/4245755/9129f0c9397a/jaos-22-05-0426-g01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f754/4245755/daea9726f3f7/jaos-22-05-0426-g02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f754/4245755/3a484d8cd37f/jaos-22-05-0426-g03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f754/4245755/4707afc6bdc7/jaos-22-05-0426-g04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f754/4245755/9bde4112a1c4/jaos-22-05-0426-g05.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f754/4245755/9129f0c9397a/jaos-22-05-0426-g01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f754/4245755/daea9726f3f7/jaos-22-05-0426-g02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f754/4245755/3a484d8cd37f/jaos-22-05-0426-g03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f754/4245755/4707afc6bdc7/jaos-22-05-0426-g04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f754/4245755/9bde4112a1c4/jaos-22-05-0426-g05.jpg

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